| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BRD8 | SMARCC2 | ENSP00000254900 | ENSP00000267064 | Bromodomain-containing protein 8; May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other prote [...] | SWI/SNF complex subunit SMARCC2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-s [...] | 0.590 |
| BRD8 | ZNF25 | ENSP00000254900 | ENSP00000302222 | Bromodomain-containing protein 8; May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other prote [...] | Zinc finger protein 25; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.558 |
| NFIX | ZNF25 | ENSP00000380781 | ENSP00000302222 | Nuclear factor 1 X-type; Recognizes and binds the palindromic sequence 5’- TTGGCNNNNNGCCAA-3’ present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication | Zinc finger protein 25; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.440 |
| RANBP3L | ZNF25 | ENSP00000421853 | ENSP00000302222 | Ran-binding protein 3-like; Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner | Zinc finger protein 25; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.575 |
| RASGEF1C | ZNF25 | ENSP00000377037 | ENSP00000302222 | Ras-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF) | Zinc finger protein 25; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.445 |
| SCRN1 | ZNF25 | ENSP00000388942 | ENSP00000302222 | Secernin-1; Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity) | Zinc finger protein 25; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.547 |
| SMARCC2 | BRD8 | ENSP00000267064 | ENSP00000254900 | SWI/SNF complex subunit SMARCC2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-s [...] | Bromodomain-containing protein 8; May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other prote [...] | 0.590 |
| SMARCC2 | TRIM28 | ENSP00000267064 | ENSP00000253024 | SWI/SNF complex subunit SMARCC2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-s [...] | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.444 |
| SMARCC2 | ZNF25 | ENSP00000267064 | ENSP00000302222 | SWI/SNF complex subunit SMARCC2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-s [...] | Zinc finger protein 25; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.484 |
| SUPT3H | ZNF25 | ENSP00000360515 | ENSP00000302222 | Transcription initiation protein SPT3 homolog; Probable transcriptional activator; SAGA complex | Zinc finger protein 25; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.531 |
| TRIM28 | SMARCC2 | ENSP00000253024 | ENSP00000267064 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | SWI/SNF complex subunit SMARCC2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-s [...] | 0.444 |
| TRIM28 | ZNF25 | ENSP00000253024 | ENSP00000302222 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 25; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.947 |
| ZBTB21 | ZNF25 | ENSP00000308759 | ENSP00000302222 | Zinc finger and BTB domain-containing protein 21; Acts as a transcription repressor; BTB domain containing | Zinc finger protein 25; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.510 |
| ZBTB21 | ZZZ3 | ENSP00000308759 | ENSP00000359837 | Zinc finger and BTB domain-containing protein 21; Acts as a transcription repressor; BTB domain containing | ZZ-type zinc finger-containing protein 3; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 | 0.582 |
| ZNF25 | BRD8 | ENSP00000302222 | ENSP00000254900 | Zinc finger protein 25; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Bromodomain-containing protein 8; May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other prote [...] | 0.558 |
| ZNF25 | NFIX | ENSP00000302222 | ENSP00000380781 | Zinc finger protein 25; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Nuclear factor 1 X-type; Recognizes and binds the palindromic sequence 5’- TTGGCNNNNNGCCAA-3’ present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication | 0.440 |
| ZNF25 | RANBP3L | ENSP00000302222 | ENSP00000421853 | Zinc finger protein 25; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Ran-binding protein 3-like; Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner | 0.575 |
| ZNF25 | RASGEF1C | ENSP00000302222 | ENSP00000377037 | Zinc finger protein 25; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Ras-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF) | 0.445 |
| ZNF25 | SCRN1 | ENSP00000302222 | ENSP00000388942 | Zinc finger protein 25; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Secernin-1; Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity) | 0.547 |
| ZNF25 | SMARCC2 | ENSP00000302222 | ENSP00000267064 | Zinc finger protein 25; May be involved in transcriptional regulation; Zinc fingers C2H2-type | SWI/SNF complex subunit SMARCC2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-s [...] | 0.484 |
