• Version:
  • 11.0 [archived version]
STRINGSTRING
LIF LIF F8A3 F8A3 F8A2 F8A2 F8A1 F8A1 GREB1 GREB1 BEST1 BEST1 ECEL1 ECEL1 RPS12 RPS12 PROSER1 PROSER1 NXPH3 NXPH3 CHRND CHRND
"ECEL1" - Endothelin-converting enzyme-like 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
ECEL1Endothelin-converting enzyme-like 1; May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides; M13 metallopeptidases (775 aa)    
Predicted Functional Partners:
NXPH3
Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity); Belongs to the neurexophilin family (252 aa)
     
   
  0.647
LIF
Leukemia inhibitory factor; LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes; Endogenous ligands (202 aa)
           
  0.521
F8A1
Factor VIII intron 22 protein; Not known. Possible housekeeping role (371 aa)
           
  0.507
F8A3
Coagulation factor VIII-associated 3; Not known. Possible housekeeping role (371 aa)
           
  0.507
GREB1
Protein GREB1; May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers (1949 aa)
           
  0.504
F8A2
Coagulation factor VIII-associated 2; Not known. Possible housekeeping role (371 aa)
           
  0.504
RPS12
Ribosomal protein S12 (132 aa)
           
  0.489
PROSER1
Proline and serine rich 1 (944 aa)
           
  0.443
CHRND
Acetylcholine receptor subunit delta; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Delta/CHRND sub-subfamily (517 aa)
           
  0.429
BEST1
Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate; Bestrophins (604 aa)
           
  0.418
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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