node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BPIFB2 | SCARA3 | ENSP00000170150 | ENSP00000301904 | BPI fold containing family B member 2; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family | Scavenger receptor class A member 3; Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation; Scavenger receptors | 0.559 |
CPSF2 | CPSF3 | ENSP00000298875 | ENSP00000238112 | Cleavage and polyadenylation specificity factor subunit 2; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3’ end pre-mRNA processing; Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily | Cleavage and polyadenylation specificity factor subunit 3; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3’-end-processing endonuclease. Also involved in the histone 3’-end pre-mRNA processing. U7 snRNP- dependent protein that induces both the 3’-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5’ t [...] | 0.999 |
CPSF2 | DCLRE1A | ENSP00000298875 | ENSP00000355185 | Cleavage and polyadenylation specificity factor subunit 2; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3’ end pre-mRNA processing; Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily | DNA cross-link repair 1A protein; May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons | 0.869 |
CPSF2 | SCARA3 | ENSP00000298875 | ENSP00000301904 | Cleavage and polyadenylation specificity factor subunit 2; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3’ end pre-mRNA processing; Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily | Scavenger receptor class A member 3; Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation; Scavenger receptors | 0.711 |
CPSF3 | CPSF2 | ENSP00000238112 | ENSP00000298875 | Cleavage and polyadenylation specificity factor subunit 3; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3’-end-processing endonuclease. Also involved in the histone 3’-end pre-mRNA processing. U7 snRNP- dependent protein that induces both the 3’-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5’ t [...] | Cleavage and polyadenylation specificity factor subunit 2; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3’ end pre-mRNA processing; Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily | 0.999 |
CPSF3 | DCLRE1A | ENSP00000238112 | ENSP00000355185 | Cleavage and polyadenylation specificity factor subunit 3; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3’-end-processing endonuclease. Also involved in the histone 3’-end pre-mRNA processing. U7 snRNP- dependent protein that induces both the 3’-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5’ t [...] | DNA cross-link repair 1A protein; May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons | 0.841 |
CPSF3 | SCARA3 | ENSP00000238112 | ENSP00000301904 | Cleavage and polyadenylation specificity factor subunit 3; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3’-end-processing endonuclease. Also involved in the histone 3’-end pre-mRNA processing. U7 snRNP- dependent protein that induces both the 3’-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5’ t [...] | Scavenger receptor class A member 3; Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation; Scavenger receptors | 0.980 |
DCLRE1A | CPSF2 | ENSP00000355185 | ENSP00000298875 | DNA cross-link repair 1A protein; May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons | Cleavage and polyadenylation specificity factor subunit 2; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3’ end pre-mRNA processing; Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily | 0.869 |
DCLRE1A | CPSF3 | ENSP00000355185 | ENSP00000238112 | DNA cross-link repair 1A protein; May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons | Cleavage and polyadenylation specificity factor subunit 3; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3’-end-processing endonuclease. Also involved in the histone 3’-end pre-mRNA processing. U7 snRNP- dependent protein that induces both the 3’-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5’ t [...] | 0.841 |
DCLRE1A | SCARA3 | ENSP00000355185 | ENSP00000301904 | DNA cross-link repair 1A protein; May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons | Scavenger receptor class A member 3; Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation; Scavenger receptors | 0.542 |
FBF1 | SCARA3 | ENSP00000324292 | ENSP00000301904 | Fas-binding factor 1; Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis | Scavenger receptor class A member 3; Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation; Scavenger receptors | 0.528 |
HPSE | SCARA3 | ENSP00000384262 | ENSP00000301904 | Heparanase; Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at ne [...] | Scavenger receptor class A member 3; Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation; Scavenger receptors | 0.567 |
LIN9 | SCARA3 | ENSP00000329102 | ENSP00000301904 | Protein lin-9 homolog; Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition; Belongs to the lin-9 family | Scavenger receptor class A member 3; Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation; Scavenger receptors | 0.552 |
PPP1R8 | SCARA3 | ENSP00000311677 | ENSP00000301904 | Nuclear inhibitor of protein phosphatase 1; Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation | Scavenger receptor class A member 3; Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation; Scavenger receptors | 0.630 |
SCARA3 | BPIFB2 | ENSP00000301904 | ENSP00000170150 | Scavenger receptor class A member 3; Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation; Scavenger receptors | BPI fold containing family B member 2; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family | 0.559 |
SCARA3 | CPSF2 | ENSP00000301904 | ENSP00000298875 | Scavenger receptor class A member 3; Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation; Scavenger receptors | Cleavage and polyadenylation specificity factor subunit 2; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3’ end pre-mRNA processing; Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily | 0.711 |
SCARA3 | CPSF3 | ENSP00000301904 | ENSP00000238112 | Scavenger receptor class A member 3; Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation; Scavenger receptors | Cleavage and polyadenylation specificity factor subunit 3; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3’-end-processing endonuclease. Also involved in the histone 3’-end pre-mRNA processing. U7 snRNP- dependent protein that induces both the 3’-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5’ t [...] | 0.980 |
SCARA3 | DCLRE1A | ENSP00000301904 | ENSP00000355185 | Scavenger receptor class A member 3; Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation; Scavenger receptors | DNA cross-link repair 1A protein; May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons | 0.542 |
SCARA3 | FBF1 | ENSP00000301904 | ENSP00000324292 | Scavenger receptor class A member 3; Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation; Scavenger receptors | Fas-binding factor 1; Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis | 0.528 |
SCARA3 | HPSE | ENSP00000301904 | ENSP00000384262 | Scavenger receptor class A member 3; Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation; Scavenger receptors | Heparanase; Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at ne [...] | 0.567 |