| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HRAS | HRASLS5 | ENSP00000407586 | ENSP00000301790 | GTPase HRas; Involved in the activation of Ras protein signal transduction. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family | Ca(2+)-independent N-acyltransferase; Catalyzes N-acylation of phosphatidylethanolamine (PE) to generate N-Acylphosphatidylethanolamine (NAPE) a precursor of bioactive N-acylethanolamines, including the endocannabinoid anandamide; Belongs to the H-rev107 family | 0.594 |
| HRASLS5 | HRAS | ENSP00000301790 | ENSP00000407586 | Ca(2+)-independent N-acyltransferase; Catalyzes N-acylation of phosphatidylethanolamine (PE) to generate N-Acylphosphatidylethanolamine (NAPE) a precursor of bioactive N-acylethanolamines, including the endocannabinoid anandamide; Belongs to the H-rev107 family | GTPase HRas; Involved in the activation of Ras protein signal transduction. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family | 0.594 |
| HRASLS5 | KLHDC3 | ENSP00000301790 | ENSP00000313995 | Ca(2+)-independent N-acyltransferase; Catalyzes N-acylation of phosphatidylethanolamine (PE) to generate N-Acylphosphatidylethanolamine (NAPE) a precursor of bioactive N-acylethanolamines, including the endocannabinoid anandamide; Belongs to the H-rev107 family | Kelch domain-containing protein 3; May be involved in meiotic recombination process | 0.541 |
| HRASLS5 | MEA1 | ENSP00000301790 | ENSP00000244711 | Ca(2+)-independent N-acyltransferase; Catalyzes N-acylation of phosphatidylethanolamine (PE) to generate N-Acylphosphatidylethanolamine (NAPE) a precursor of bioactive N-acylethanolamines, including the endocannabinoid anandamide; Belongs to the H-rev107 family | Male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development | 0.558 |
| HRASLS5 | NFKBIZ | ENSP00000301790 | ENSP00000325663 | Ca(2+)-independent N-acyltransferase; Catalyzes N-acylation of phosphatidylethanolamine (PE) to generate N-Acylphosphatidylethanolamine (NAPE) a precursor of bioactive N-acylethanolamines, including the endocannabinoid anandamide; Belongs to the H-rev107 family | NF-kappa-B inhibitor zeta; Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF- kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promot [...] | 0.790 |
| HRASLS5 | PHF7 | ENSP00000301790 | ENSP00000333024 | Ca(2+)-independent N-acyltransferase; Catalyzes N-acylation of phosphatidylethanolamine (PE) to generate N-Acylphosphatidylethanolamine (NAPE) a precursor of bioactive N-acylethanolamines, including the endocannabinoid anandamide; Belongs to the H-rev107 family | PHD finger protein 7; May play a role in spermatogenesis; PHD finger proteins | 0.501 |
| HRASLS5 | SCN1A | ENSP00000301790 | ENSP00000303540 | Ca(2+)-independent N-acyltransferase; Catalyzes N-acylation of phosphatidylethanolamine (PE) to generate N-Acylphosphatidylethanolamine (NAPE) a precursor of bioactive N-acylethanolamines, including the endocannabinoid anandamide; Belongs to the H-rev107 family | Sodium channel protein type 1 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain- activation in somatosensory neurons induces pain without neurogenic inflammatio [...] | 0.567 |
| HRASLS5 | SCN8A | ENSP00000301790 | ENSP00000346534 | Ca(2+)-independent N-acyltransferase; Catalyzes N-acylation of phosphatidylethanolamine (PE) to generate N-Acylphosphatidylethanolamine (NAPE) a precursor of bioactive N-acylethanolamines, including the endocannabinoid anandamide; Belongs to the H-rev107 family | Sodium channel protein type 8 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation; Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily | 0.545 |
| HRASLS5 | SPATA4 | ENSP00000301790 | ENSP00000280191 | Ca(2+)-independent N-acyltransferase; Catalyzes N-acylation of phosphatidylethanolamine (PE) to generate N-Acylphosphatidylethanolamine (NAPE) a precursor of bioactive N-acylethanolamines, including the endocannabinoid anandamide; Belongs to the H-rev107 family | Spermatogenesis-associated protein 4; Spermatogenesis associated 4 | 0.570 |
| HRASLS5 | SPZ1 | ENSP00000301790 | ENSP00000369611 | Ca(2+)-independent N-acyltransferase; Catalyzes N-acylation of phosphatidylethanolamine (PE) to generate N-Acylphosphatidylethanolamine (NAPE) a precursor of bioactive N-acylethanolamines, including the endocannabinoid anandamide; Belongs to the H-rev107 family | Spermatogenic leucine zipper protein 1; Transcription factor that binds to the DNA sequence 5’- CANNTG-3’(E box) and the G-box motif. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis (By similarity); Protein phosphatase 1 regulatory subunits | 0.525 |
| HRASLS5 | STRA6 | ENSP00000301790 | ENSP00000456609 | Ca(2+)-independent N-acyltransferase; Catalyzes N-acylation of phosphatidylethanolamine (PE) to generate N-Acylphosphatidylethanolamine (NAPE) a precursor of bioactive N-acylethanolamines, including the endocannabinoid anandamide; Belongs to the H-rev107 family | Receptor for retinol uptake STRA6; Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1. Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A. Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and it [...] | 0.560 |
| KLHDC3 | HRASLS5 | ENSP00000313995 | ENSP00000301790 | Kelch domain-containing protein 3; May be involved in meiotic recombination process | Ca(2+)-independent N-acyltransferase; Catalyzes N-acylation of phosphatidylethanolamine (PE) to generate N-Acylphosphatidylethanolamine (NAPE) a precursor of bioactive N-acylethanolamines, including the endocannabinoid anandamide; Belongs to the H-rev107 family | 0.541 |
| KLHDC3 | MEA1 | ENSP00000313995 | ENSP00000244711 | Kelch domain-containing protein 3; May be involved in meiotic recombination process | Male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development | 0.907 |
| KLHDC3 | PHF7 | ENSP00000313995 | ENSP00000333024 | Kelch domain-containing protein 3; May be involved in meiotic recombination process | PHD finger protein 7; May play a role in spermatogenesis; PHD finger proteins | 0.417 |
| KLHDC3 | SPATA4 | ENSP00000313995 | ENSP00000280191 | Kelch domain-containing protein 3; May be involved in meiotic recombination process | Spermatogenesis-associated protein 4; Spermatogenesis associated 4 | 0.499 |
| KLHDC3 | SPZ1 | ENSP00000313995 | ENSP00000369611 | Kelch domain-containing protein 3; May be involved in meiotic recombination process | Spermatogenic leucine zipper protein 1; Transcription factor that binds to the DNA sequence 5’- CANNTG-3’(E box) and the G-box motif. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis (By similarity); Protein phosphatase 1 regulatory subunits | 0.444 |
| MEA1 | HRASLS5 | ENSP00000244711 | ENSP00000301790 | Male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development | Ca(2+)-independent N-acyltransferase; Catalyzes N-acylation of phosphatidylethanolamine (PE) to generate N-Acylphosphatidylethanolamine (NAPE) a precursor of bioactive N-acylethanolamines, including the endocannabinoid anandamide; Belongs to the H-rev107 family | 0.558 |
| MEA1 | KLHDC3 | ENSP00000244711 | ENSP00000313995 | Male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development | Kelch domain-containing protein 3; May be involved in meiotic recombination process | 0.907 |
| MEA1 | PHF7 | ENSP00000244711 | ENSP00000333024 | Male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development | PHD finger protein 7; May play a role in spermatogenesis; PHD finger proteins | 0.496 |
| MEA1 | SPATA4 | ENSP00000244711 | ENSP00000280191 | Male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development | Spermatogenesis-associated protein 4; Spermatogenesis associated 4 | 0.542 |
