| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BIRC5 | DTYMK | ENSP00000301633 | ENSP00000304802 | Baculoviral IAP repeat containing 5 | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family | 0.483 |
| BIRC5 | DUT | ENSP00000301633 | ENSP00000370376 | Baculoviral IAP repeat containing 5 | Deoxyuridine 5’-triphosphate nucleotidohydrolase, mitochondrial; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family | 0.444 |
| BIRC5 | E2F1 | ENSP00000301633 | ENSP00000345571 | Baculoviral IAP repeat containing 5 | Transcription factor E2F1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA bind [...] | 0.558 |
| BIRC5 | TK1 | ENSP00000301633 | ENSP00000301634 | Baculoviral IAP repeat containing 5 | Thymidine kinase, cytosolic; Thymidine kinase 1; Belongs to the thymidine kinase family | 0.939 |
| BIRC5 | TYMS | ENSP00000301633 | ENSP00000315644 | Baculoviral IAP repeat containing 5 | Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway | 0.846 |
| CDA | DCTD | ENSP00000364212 | ENSP00000349576 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase | 0.891 |
| CDA | DTYMK | ENSP00000364212 | ENSP00000304802 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family | 0.565 |
| CDA | DUT | ENSP00000364212 | ENSP00000370376 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Deoxyuridine 5’-triphosphate nucleotidohydrolase, mitochondrial; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family | 0.411 |
| CDA | PNP | ENSP00000364212 | ENSP00000354532 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate | 0.976 |
| CDA | TK1 | ENSP00000364212 | ENSP00000301634 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Thymidine kinase, cytosolic; Thymidine kinase 1; Belongs to the thymidine kinase family | 0.980 |
| CDA | TYMP | ENSP00000364212 | ENSP00000379038 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Thymidine phosphorylase; May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro; Minor histocompatibility antigens | 0.997 |
| CDA | TYMS | ENSP00000364212 | ENSP00000315644 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway | 0.723 |
| CDA | UPP1 | ENSP00000364212 | ENSP00000330032 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Uridine phosphorylase 1; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis; Belongs to the PNP/UDP phosphorylase family | 0.977 |
| DCTD | CDA | ENSP00000349576 | ENSP00000364212 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | 0.891 |
| DCTD | DTYMK | ENSP00000349576 | ENSP00000304802 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family | 0.976 |
| DCTD | DUT | ENSP00000349576 | ENSP00000370376 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase | Deoxyuridine 5’-triphosphate nucleotidohydrolase, mitochondrial; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family | 0.978 |
| DCTD | TK1 | ENSP00000349576 | ENSP00000301634 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase | Thymidine kinase, cytosolic; Thymidine kinase 1; Belongs to the thymidine kinase family | 0.967 |
| DCTD | TYMP | ENSP00000349576 | ENSP00000379038 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase | Thymidine phosphorylase; May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro; Minor histocompatibility antigens | 0.486 |
| DCTD | TYMS | ENSP00000349576 | ENSP00000315644 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase | Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway | 0.993 |
| DCTD | UPP1 | ENSP00000349576 | ENSP00000330032 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase | Uridine phosphorylase 1; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis; Belongs to the PNP/UDP phosphorylase family | 0.521 |
