| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANAPC16 | CYB5D2 | ENSP00000477760 | ENSP00000301391 | Anaphase-promoting complex subunit 16; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains; Belongs to the APC16 family | Neuferricin; Heme-binding protein which promotes neuronal but not astrocyte differentiation; Membrane associated progesterone receptor family | 0.761 |
| B4GALNT1 | CYB5D2 | ENSP00000341562 | ENSP00000301391 | Beta-1,4 N-acetylgalactosaminyltransferase 1; Involved in the biosynthesis of gangliosides GM2, GD2 and GA2; Beta 4-glycosyltransferases | Neuferricin; Heme-binding protein which promotes neuronal but not astrocyte differentiation; Membrane associated progesterone receptor family | 0.626 |
| B4GALNT1 | GRM6 | ENSP00000341562 | ENSP00000231188 | Beta-1,4 N-acetylgalactosaminyltransferase 1; Involved in the biosynthesis of gangliosides GM2, GD2 and GA2; Beta 4-glycosyltransferases | Metabotropic glutamate receptor 6; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision; Glutamate metabotropic receptors | 0.626 |
| B4GALNT1 | ST3GAL5 | ENSP00000341562 | ENSP00000366549 | Beta-1,4 N-acetylgalactosaminyltransferase 1; Involved in the biosynthesis of gangliosides GM2, GD2 and GA2; Beta 4-glycosyltransferases | Lactosylceramide alpha-2,3-sialyltransferase; Catalyzes the formation of ganglioside GM3 (alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D- glucosylceramide); Sialyltransferases | 0.971 |
| B4GALNT1 | ST8SIA1 | ENSP00000341562 | ENSP00000379353 | Beta-1,4 N-acetylgalactosaminyltransferase 1; Involved in the biosynthesis of gangliosides GM2, GD2 and GA2; Beta 4-glycosyltransferases | Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid; Sialyltransferases | 0.974 |
| CYB5A | CYB5D2 | ENSP00000341625 | ENSP00000301391 | Cytochrome b5; Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases | Neuferricin; Heme-binding protein which promotes neuronal but not astrocyte differentiation; Membrane associated progesterone receptor family | 0.750 |
| CYB5D2 | ANAPC16 | ENSP00000301391 | ENSP00000477760 | Neuferricin; Heme-binding protein which promotes neuronal but not astrocyte differentiation; Membrane associated progesterone receptor family | Anaphase-promoting complex subunit 16; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains; Belongs to the APC16 family | 0.761 |
| CYB5D2 | B4GALNT1 | ENSP00000301391 | ENSP00000341562 | Neuferricin; Heme-binding protein which promotes neuronal but not astrocyte differentiation; Membrane associated progesterone receptor family | Beta-1,4 N-acetylgalactosaminyltransferase 1; Involved in the biosynthesis of gangliosides GM2, GD2 and GA2; Beta 4-glycosyltransferases | 0.626 |
| CYB5D2 | CYB5A | ENSP00000301391 | ENSP00000341625 | Neuferricin; Heme-binding protein which promotes neuronal but not astrocyte differentiation; Membrane associated progesterone receptor family | Cytochrome b5; Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases | 0.750 |
| CYB5D2 | GM2A | ENSP00000301391 | ENSP00000349687 | Neuferricin; Heme-binding protein which promotes neuronal but not astrocyte differentiation; Membrane associated progesterone receptor family | Ganglioside GM2 activator; The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 | 0.583 |
| CYB5D2 | GRM6 | ENSP00000301391 | ENSP00000231188 | Neuferricin; Heme-binding protein which promotes neuronal but not astrocyte differentiation; Membrane associated progesterone receptor family | Metabotropic glutamate receptor 6; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision; Glutamate metabotropic receptors | 0.626 |
| CYB5D2 | MGEA5 | ENSP00000301391 | ENSP00000354850 | Neuferricin; Heme-binding protein which promotes neuronal but not astrocyte differentiation; Membrane associated progesterone receptor family | Protein O-GlcNAcase; Isoform 1- Cleaves GlcNAc but not GalNAc from O- glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4- methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl- beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro). Does not bind acetyl-CoA and does not have histone acetyltransferase activity; Belongs to the glycosyl hydrolase 84 family | 0.576 |
| CYB5D2 | PAQR5 | ENSP00000301391 | ENSP00000378803 | Neuferricin; Heme-binding protein which promotes neuronal but not astrocyte differentiation; Membrane associated progesterone receptor family | Membrane progestin receptor gamma; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation; Progestin and adipoQ receptor family | 0.578 |
| CYB5D2 | PGR | ENSP00000301391 | ENSP00000325120 | Neuferricin; Heme-binding protein which promotes neuronal but not astrocyte differentiation; Membrane associated progesterone receptor family | Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor; Belongs to the nuclear hormone receptor family. NR3 subfamily | 0.567 |
| CYB5D2 | ST3GAL5 | ENSP00000301391 | ENSP00000366549 | Neuferricin; Heme-binding protein which promotes neuronal but not astrocyte differentiation; Membrane associated progesterone receptor family | Lactosylceramide alpha-2,3-sialyltransferase; Catalyzes the formation of ganglioside GM3 (alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D- glucosylceramide); Sialyltransferases | 0.572 |
| CYB5D2 | ST8SIA1 | ENSP00000301391 | ENSP00000379353 | Neuferricin; Heme-binding protein which promotes neuronal but not astrocyte differentiation; Membrane associated progesterone receptor family | Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid; Sialyltransferases | 0.572 |
| GM2A | CYB5D2 | ENSP00000349687 | ENSP00000301391 | Ganglioside GM2 activator; The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 | Neuferricin; Heme-binding protein which promotes neuronal but not astrocyte differentiation; Membrane associated progesterone receptor family | 0.583 |
| GM2A | MGEA5 | ENSP00000349687 | ENSP00000354850 | Ganglioside GM2 activator; The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 | Protein O-GlcNAcase; Isoform 1- Cleaves GlcNAc but not GalNAc from O- glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4- methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl- beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro). Does not bind acetyl-CoA and does not have histone acetyltransferase activity; Belongs to the glycosyl hydrolase 84 family | 0.713 |
| GRM6 | B4GALNT1 | ENSP00000231188 | ENSP00000341562 | Metabotropic glutamate receptor 6; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision; Glutamate metabotropic receptors | Beta-1,4 N-acetylgalactosaminyltransferase 1; Involved in the biosynthesis of gangliosides GM2, GD2 and GA2; Beta 4-glycosyltransferases | 0.626 |
| GRM6 | CYB5D2 | ENSP00000231188 | ENSP00000301391 | Metabotropic glutamate receptor 6; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision; Glutamate metabotropic receptors | Neuferricin; Heme-binding protein which promotes neuronal but not astrocyte differentiation; Membrane associated progesterone receptor family | 0.626 |
