GLOD4 protein (human) - STRING database

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GLOD4

Glyoxalase domain containing 4 (298 aa)

Predicted Functional Partners:

NANS

0.870

WDR82

0.867

GLRX5

0.837

PPIL3

0.834

CCDC60

0.773

C1orf101

0.701

GLO1

0.694

PARK7

0.676

LRRC47

0.672

PRDX2

0.662

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1orf101	CCDC60	ENSP00000355492	ENSP00000333374	Cation channel sperm-associated protein subunit epsilon; Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization; Belongs to the CATSPERD family	Coiled-coil domain containing 60	0.805
C1orf101	GLOD4	ENSP00000355492	ENSP00000301329	Cation channel sperm-associated protein subunit epsilon; Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization; Belongs to the CATSPERD family	Glyoxalase domain containing 4	0.701
CCDC60	C1orf101	ENSP00000333374	ENSP00000355492	Coiled-coil domain containing 60	Cation channel sperm-associated protein subunit epsilon; Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization; Belongs to the CATSPERD family	0.805
CCDC60	GLOD4	ENSP00000333374	ENSP00000301329	Coiled-coil domain containing 60	Glyoxalase domain containing 4	0.773
GLO1	GLOD4	ENSP00000362463	ENSP00000301329	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B. Required for normal osteoclastogenesis	Glyoxalase domain containing 4	0.694
GLO1	PARK7	ENSP00000362463	ENSP00000418770	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B. Required for normal osteoclastogenesis	Protein/nucleic acid deglycase DJ-1; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminoca [...]	0.817
GLOD4	C1orf101	ENSP00000301329	ENSP00000355492	Glyoxalase domain containing 4	Cation channel sperm-associated protein subunit epsilon; Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization; Belongs to the CATSPERD family	0.701
GLOD4	CCDC60	ENSP00000301329	ENSP00000333374	Glyoxalase domain containing 4	Coiled-coil domain containing 60	0.773
GLOD4	GLO1	ENSP00000301329	ENSP00000362463	Glyoxalase domain containing 4	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B. Required for normal osteoclastogenesis	0.694
GLOD4	GLRX5	ENSP00000301329	ENSP00000328570	Glyoxalase domain containing 4	Glutaredoxin-related protein 5, mitochondrial; Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1. May protect cells against apoptosis due to reactive oxygen species and oxidative stress (By similarity)	0.837
GLOD4	LRRC47	ENSP00000301329	ENSP00000367498	Glyoxalase domain containing 4	Leucine-rich repeat-containing protein 47; Leucine rich repeat containing 47	0.672
GLOD4	NANS	ENSP00000301329	ENSP00000210444	Glyoxalase domain containing 4	Sialic acid synthase; Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3- deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N- acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively	0.870
GLOD4	PARK7	ENSP00000301329	ENSP00000418770	Glyoxalase domain containing 4	Protein/nucleic acid deglycase DJ-1; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminoca [...]	0.676
GLOD4	PPIL3	ENSP00000301329	ENSP00000286175	Glyoxalase domain containing 4	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Cyclophilin peptidylprolyl isomerases	0.834
GLOD4	PRDX2	ENSP00000301329	ENSP00000301522	Glyoxalase domain containing 4	Peroxiredoxin-2; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2); Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily	0.662
GLOD4	WDR82	ENSP00000301329	ENSP00000296490	Glyoxalase domain containing 4	WD repeat-containing protein 82; Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 ’Lys-4’ methylation via recruitment of the SETD1A or SETD1B to the ’Ser-5’ phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase; WD repeat domain containing	0.867
GLRX5	GLOD4	ENSP00000328570	ENSP00000301329	Glutaredoxin-related protein 5, mitochondrial; Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1. May protect cells against apoptosis due to reactive oxygen species and oxidative stress (By similarity)	Glyoxalase domain containing 4	0.837
GLRX5	PRDX2	ENSP00000328570	ENSP00000301522	Glutaredoxin-related protein 5, mitochondrial; Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1. May protect cells against apoptosis due to reactive oxygen species and oxidative stress (By similarity)	Peroxiredoxin-2; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2); Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily	0.491
LRRC47	GLOD4	ENSP00000367498	ENSP00000301329	Leucine-rich repeat-containing protein 47; Leucine rich repeat containing 47	Glyoxalase domain containing 4	0.672
NANS	GLOD4	ENSP00000210444	ENSP00000301329	Sialic acid synthase; Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3- deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N- acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively	Glyoxalase domain containing 4	0.870

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