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  • 11.0 [archived version]
STRINGSTRING
DNAJC3 DNAJC3 MFSD11 MFSD11 MFSD3 MFSD3 HIATL1 HIATL1 MFSD1 MFSD1 TMEM180 TMEM180 MFSD9 MFSD9 MFSD5 MFSD5 MFSD12 MFSD12 MFSD6L MFSD6L UNC93A UNC93A
"MFSD3" - Major facilitator superfamily domain containing 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Cooccurence
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[Homology]
Score
MFSD3Major facilitator superfamily domain containing 3 (412 aa)    
Predicted Functional Partners:
MFSD12
Major facilitator superfamily domain containing 12 (480 aa)
   
   
  0.719
MFSD11
UNC93-like protein MFSD11; Major facilitator superfamily domain containing 11; Belongs to the unc-93 family (449 aa)
      
   
  0.698
MFSD6L
Major facilitator superfamily domain containing 6 like (586 aa)
            
  0.687
HIATL1
Hippocampus abundant transcript-like 1; Belongs to the major facilitator superfamily (506 aa)
      
   
  0.687
TMEM180
Transmembrane protein 180 (517 aa)
      
   
  0.684
MFSD5
Molybdate-anion transporter; Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum; Belongs to the major facilitator superfamily (557 aa)
      
   
  0.669
DNAJC3
DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at ’Ser-52’ and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2 [...] (504 aa)
      
 
  0.659
MFSD1
Major facilitator superfamily domain containing 1 (514 aa)
            
  0.630
MFSD9
Major facilitator superfamily domain containing 9 (474 aa)
      
   
  0.613
UNC93A
Unc-93 homolog A; Belongs to the unc-93 family (457 aa)
            
  0.610
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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