node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C2CD4C | ELFN2 | ENSP00000328677 | ENSP00000385277 | C2 calcium-dependent domain-containing protein 4C; C2 calcium dependent domain containing 4C; Belongs to the C2CD4 family | Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing | 0.623 |
C2CD4C | HMHA1 | ENSP00000328677 | ENSP00000439601 | C2 calcium-dependent domain-containing protein 4C; C2 calcium dependent domain containing 4C; Belongs to the C2CD4 family | Rho GTPase-activating protein 45; Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity | 0.549 |
C2CD4C | KIAA0020 | ENSP00000328677 | ENSP00000380982 | C2 calcium-dependent domain-containing protein 4C; C2 calcium dependent domain containing 4C; Belongs to the C2CD4 family | Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells (By similarity) | 0.541 |
C2CD4C | PHACTR2 | ENSP00000328677 | ENSP00000417038 | C2 calcium-dependent domain-containing protein 4C; C2 calcium dependent domain containing 4C; Belongs to the C2CD4 family | Phosphatase and actin regulator 2 | 0.529 |
C2CD4C | PPP1R18 | ENSP00000328677 | ENSP00000274853 | C2 calcium-dependent domain-containing protein 4C; C2 calcium dependent domain containing 4C; Belongs to the C2CD4 family | Phostensin; Isoform 1- May target protein phosphatase 1 to F-actin cytoskeleton | 0.559 |
C2CD4C | PTCHD2 | ENSP00000328677 | ENSP00000294484 | C2 calcium-dependent domain-containing protein 4C; C2 calcium dependent domain containing 4C; Belongs to the C2CD4 family | Protein dispatched homolog 3; Plays a role in neuronal proliferation and differentiation. Plays a role in the accumulation of cellular cholesterol (By similarity). Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells (By similarity) | 0.544 |
C2CD4C | ZC3H3 | ENSP00000328677 | ENSP00000262577 | C2 calcium-dependent domain-containing protein 4C; C2 calcium dependent domain containing 4C; Belongs to the C2CD4 family | Zinc finger CCCH domain-containing protein 3; Required for the export of polyadenylated mRNAs from the nucleus. Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double- stranded DNA in vitro. Involved in RNA cleavage (By similarity); Zinc fingers CCCH-type | 0.553 |
C2CD4C | ZFP28 | ENSP00000328677 | ENSP00000301318 | C2 calcium-dependent domain-containing protein 4C; C2 calcium dependent domain containing 4C; Belongs to the C2CD4 family | Zinc finger protein 28 homolog; May be involved in transcriptional regulation. May have a role in embryonic development; Zinc fingers C2H2-type | 0.551 |
CCDC43 | ZFP28 | ENSP00000323782 | ENSP00000301318 | Coiled-coil domain containing 43; Belongs to the CCDC43 family | Zinc finger protein 28 homolog; May be involved in transcriptional regulation. May have a role in embryonic development; Zinc fingers C2H2-type | 0.626 |
ELFN2 | C2CD4C | ENSP00000385277 | ENSP00000328677 | Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing | C2 calcium-dependent domain-containing protein 4C; C2 calcium dependent domain containing 4C; Belongs to the C2CD4 family | 0.623 |
ELFN2 | HMHA1 | ENSP00000385277 | ENSP00000439601 | Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing | Rho GTPase-activating protein 45; Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity | 0.512 |
ELFN2 | KIAA0020 | ENSP00000385277 | ENSP00000380982 | Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing | Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells (By similarity) | 0.540 |
ELFN2 | PHACTR2 | ENSP00000385277 | ENSP00000417038 | Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing | Phosphatase and actin regulator 2 | 0.531 |
ELFN2 | PPP1R18 | ENSP00000385277 | ENSP00000274853 | Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing | Phostensin; Isoform 1- May target protein phosphatase 1 to F-actin cytoskeleton | 0.545 |
ELFN2 | PTCHD2 | ENSP00000385277 | ENSP00000294484 | Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing | Protein dispatched homolog 3; Plays a role in neuronal proliferation and differentiation. Plays a role in the accumulation of cellular cholesterol (By similarity). Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells (By similarity) | 0.540 |
ELFN2 | ZC3H3 | ENSP00000385277 | ENSP00000262577 | Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing | Zinc finger CCCH domain-containing protein 3; Required for the export of polyadenylated mRNAs from the nucleus. Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double- stranded DNA in vitro. Involved in RNA cleavage (By similarity); Zinc fingers CCCH-type | 0.554 |
ELFN2 | ZFP28 | ENSP00000385277 | ENSP00000301318 | Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing | Zinc finger protein 28 homolog; May be involved in transcriptional regulation. May have a role in embryonic development; Zinc fingers C2H2-type | 0.548 |
HMHA1 | C2CD4C | ENSP00000439601 | ENSP00000328677 | Rho GTPase-activating protein 45; Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity | C2 calcium-dependent domain-containing protein 4C; C2 calcium dependent domain containing 4C; Belongs to the C2CD4 family | 0.549 |
HMHA1 | ELFN2 | ENSP00000439601 | ENSP00000385277 | Rho GTPase-activating protein 45; Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity | Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing | 0.512 |
HMHA1 | KIAA0020 | ENSP00000439601 | ENSP00000380982 | Rho GTPase-activating protein 45; Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity | Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells (By similarity) | 0.622 |