| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DBNDD2 | TSTD1 | ENSP00000361795 | ENSP00000388293 | Dysbindin domain-containing protein 2; May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro); Belongs to the dysbindin family | Thiosulfate-glutathione sulfurtransferase; Thiosulfate-glutathione sulfurtransferase (TST) required to produce glutathione persulfide (GSS(-)), a central intermediate in hydrogen sulfide metabolism. Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide-quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate. The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with th [...] | 0.530 |
| DBNDD2 | ZNF582 | ENSP00000361795 | ENSP00000301310 | Dysbindin domain-containing protein 2; May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro); Belongs to the dysbindin family | Zinc finger protein 582; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.446 |
| ENSG00000242631 | ZNF582 | ENSP00000475594 | ENSP00000301310 | Zinc finger protein 462 | Zinc finger protein 582; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.533 |
| NKX6-1 | PAX1 | ENSP00000295886 | ENSP00000381499 | Homeobox protein Nkx-6.1; Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity); NKL subclass homeoboxes and pseudogenes | Paired box protein Pax-1; This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column (By similarity); Paired boxes | 0.454 |
| NKX6-1 | SOX1 | ENSP00000295886 | ENSP00000330218 | Homeobox protein Nkx-6.1; Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity); NKL subclass homeoboxes and pseudogenes | Transcription factor SOX-1; Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity); SRY-boxes | 0.567 |
| NKX6-1 | ZNF582 | ENSP00000295886 | ENSP00000301310 | Homeobox protein Nkx-6.1; Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity); NKL subclass homeoboxes and pseudogenes | Zinc finger protein 582; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.414 |
| PAX1 | NKX6-1 | ENSP00000381499 | ENSP00000295886 | Paired box protein Pax-1; This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column (By similarity); Paired boxes | Homeobox protein Nkx-6.1; Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity); NKL subclass homeoboxes and pseudogenes | 0.454 |
| PAX1 | SOX1 | ENSP00000381499 | ENSP00000330218 | Paired box protein Pax-1; This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column (By similarity); Paired boxes | Transcription factor SOX-1; Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity); SRY-boxes | 0.562 |
| PAX1 | ZNF582 | ENSP00000381499 | ENSP00000301310 | Paired box protein Pax-1; This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column (By similarity); Paired boxes | Zinc finger protein 582; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.710 |
| PCDHA13 | ZNF582 | ENSP00000289272 | ENSP00000301310 | Protocadherin alpha-13; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | Zinc finger protein 582; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.446 |
| PTPRR | ZNF582 | ENSP00000283228 | ENSP00000301310 | Receptor-type tyrosine-protein phosphatase R; Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity); Protein tyrosine phosphatases, receptor type | Zinc finger protein 582; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.538 |
| PVRL4 | ZNF582 | ENSP00000356991 | ENSP00000301310 | Nectin-4; Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells | Zinc finger protein 582; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.403 |
| SOX1 | NKX6-1 | ENSP00000330218 | ENSP00000295886 | Transcription factor SOX-1; Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity); SRY-boxes | Homeobox protein Nkx-6.1; Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity); NKL subclass homeoboxes and pseudogenes | 0.567 |
| SOX1 | PAX1 | ENSP00000330218 | ENSP00000381499 | Transcription factor SOX-1; Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity); SRY-boxes | Paired box protein Pax-1; This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column (By similarity); Paired boxes | 0.562 |
| SOX1 | ZNF582 | ENSP00000330218 | ENSP00000301310 | Transcription factor SOX-1; Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity); SRY-boxes | Zinc finger protein 582; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.600 |
| TRIM28 | ZNF582 | ENSP00000253024 | ENSP00000301310 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 582; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.925 |
| TSTD1 | DBNDD2 | ENSP00000388293 | ENSP00000361795 | Thiosulfate-glutathione sulfurtransferase; Thiosulfate-glutathione sulfurtransferase (TST) required to produce glutathione persulfide (GSS(-)), a central intermediate in hydrogen sulfide metabolism. Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide-quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate. The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with th [...] | Dysbindin domain-containing protein 2; May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro); Belongs to the dysbindin family | 0.530 |
| TSTD1 | ZNF582 | ENSP00000388293 | ENSP00000301310 | Thiosulfate-glutathione sulfurtransferase; Thiosulfate-glutathione sulfurtransferase (TST) required to produce glutathione persulfide (GSS(-)), a central intermediate in hydrogen sulfide metabolism. Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide-quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate. The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with th [...] | Zinc finger protein 582; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.473 |
| ZNF582 | DBNDD2 | ENSP00000301310 | ENSP00000361795 | Zinc finger protein 582; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Dysbindin domain-containing protein 2; May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro); Belongs to the dysbindin family | 0.446 |
| ZNF582 | ENSG00000242631 | ENSP00000301310 | ENSP00000475594 | Zinc finger protein 582; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Zinc finger protein 462 | 0.533 |
