• Version:
  • 11.0 [archived version]
STRINGSTRING
SAMD14 SAMD14 SPINT2 SPINT2 PPP1R12A PPP1R12A SMIM14 SMIM14 PPP1R14A PPP1R14A C19orf33 C19orf33 CDIPT CDIPT C3orf52 C3orf52 C4orf19 C4orf19 C11orf1 C11orf1
"C19orf33" - Immortalization up-regulated protein in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
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[Homology]
Score
C19orf33Immortalization up-regulated protein; Chromosome 19 open reading frame 33 (106 aa)    
Predicted Functional Partners:
SPINT2
Kunitz-type protease inhibitor 2; Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa (252 aa)
     
   
  0.759
PPP1R14A
Protein phosphatase 1 regulatory subunit 14A; Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (147 aa)
           
  0.757
C4orf19
Uncharacterized protein C4orf19; Chromosome 4 open reading frame 19 (314 aa)
           
  0.530
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns-inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme (213 aa)
           
  0.483
C3orf52
TPA-induced transmembrane protein; Chromosome 3 open reading frame 52 (250 aa)
           
  0.447
C11orf1
UPF0686 protein C11orf1; Chromosome 11 open reading frame 1; Belongs to the UPF0686 family (150 aa)
           
  0.429
SAMD14
Sterile alpha motif domain containing 14 (445 aa)
           
  0.422
SMIM14
Small integral membrane protein 14 (99 aa)
           
  0.418
PPP1R12A
Protein phosphatase 1 regulatory subunit 12A; Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN- dependent suppression of HIF1A activity; Ankyrin repeat domain containing (1030 aa)
           
  0.412
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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