• Version:
  • 11.0 [archived version]
STRINGSTRING
OR4K15 OR4K15 OR52B2 OR52B2 HSD11B1 HSD11B1 LCN2 LCN2 OR52M1 OR52M1 LAIR2 LAIR2 OR6K2 OR6K2 C14orf37 C14orf37 OR2T6 OR2T6 CD300C CD300C OR9G4 OR9G4
"LAIR2" - Leukocyte associated immunoglobulin like receptor 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LAIR2Leukocyte associated immunoglobulin like receptor 2; CD molecules (152 aa)    
Predicted Functional Partners:
HSD11B1
Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol (By similarity); Short chain dehydrogenase/reductase superfamily (292 aa)
           
  0.626
LCN2
Neutrophil gelatinase-associated lipocalin; Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association o [...] (198 aa)
       
      0.536
OR6K2
Olfactory receptor 6K2; Odorant receptor; Olfactory receptors, family 6 (324 aa)
           
  0.534
OR2T6
Olfactory receptor 2T6; Odorant receptor; Olfactory receptors, family 2 (308 aa)
           
  0.476
OR9G4
Olfactory receptor 9G4; Odorant receptor; Olfactory receptors, family 9 (327 aa)
           
  0.473
C14orf37
Uncharacterized protein C14orf37; Chromosome 14 open reading frame 37 (774 aa)
           
  0.444
OR52M1
Olfactory receptor 52M1; Odorant receptor; Olfactory receptors, family 52 (317 aa)
           
  0.441
OR4K15
Olfactory receptor 4K15; Odorant receptor; Olfactory receptors, family 4 (348 aa)
           
  0.441
OR52B2
Olfactory receptor 52B2; Odorant receptor; Olfactory receptors, family 52 (323 aa)
           
  0.420
CD300C
CMRF35-like molecule 6; V-set domain containing; Belongs to the CD300 family (224 aa)
     
   
  0.402
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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