• Version:
  • 11.0 [archived version]
STRINGSTRING
LARP4 LARP4 DMAP1 DMAP1 LIMA1 LIMA1 CNKSR3 CNKSR3 C11orf53 C11orf53 DIP2B DIP2B AASDH AASDH FAM186A FAM186A COLCA2 COLCA2 TMEM105 TMEM105 STK32B STK32B
"DIP2B" - Disco interacting protein 2 homolog B in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP2BDisco interacting protein 2 homolog B (1576 aa)    
Predicted Functional Partners:
CNKSR3
Connector enhancer of kinase suppressor of ras 3; Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC); PDZ domain containing (555 aa)
       
      0.826
DMAP1
DNA methyltransferase 1-associated protein 1; Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX- mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucl [...] (467 aa)
           
  0.800
LARP4
La-related protein 4; RNA binding protein that binds to the poly-A tract of mRNA molecules. Associates with the 40S ribosomal subunit and with polysomes. Plays a role in the regulation of mRNA translation. Plays a role in the regulation of cell morphology and cytoskeletal organization; La ribonucleoprotein domain containing (724 aa)
           
  0.645
C11orf53
Uncharacterized protein C11orf53; Chromosome 11 open reading frame 53 (236 aa)
           
  0.637
COLCA2
Colorectal cancer associated 2 (251 aa)
           
  0.630
TMEM105
Transmembrane protein 105 (129 aa)
           
  0.552
LIMA1
LIM domain and actin-binding protein 1; Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments; LIM domain containing (760 aa)
     
   
  0.545
FAM186A
Protein FAM186A; Family with sequence similarity 186 member A; Belongs to the FAM186 family (2351 aa)
           
  0.543
AASDH
Acyl-CoA synthetase family member 4; Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA; Acyl-CoA synthetase family (1098 aa)
   
   
  0.516
STK32B
Serine/threonine kinase 32B (414 aa)
           
  0.510
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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