• Version:
  • 11.0 [archived version]
STRINGSTRING
C9orf9 C9orf9 INCA1 INCA1 KLHDC9 KLHDC9 C16orf90 C16orf90 CCNA1 CCNA1 PROCA1 PROCA1 SUPT6H SUPT6H KLHL38 KLHL38 TBC1D22B TBC1D22B PPP2R2D PPP2R2D KIAA1191 KIAA1191
"PROCA1" - Protein interacting with cyclin A1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PROCA1Protein interacting with cyclin A1; Belongs to the PROCA1 family (336 aa)    
Predicted Functional Partners:
TBC1D22B
TBC1 domain family member 22B; May act as a GTPase-activating protein for Rab family protein(s) (505 aa)
           
  0.741
PPP2R2D
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55- delta) fluctuate during the cell cycle- the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also m [...] (453 aa)
           
  0.725
KLHDC9
Kelch domain containing 9 (349 aa)
           
  0.655
C16orf90
Uncharacterized protein C16orf90; Chromosome 16 open reading frame 90 (182 aa)
           
  0.556
CCNA1
Cyclin-A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells; Belongs to the cyclin family. Cyclin AB subfamily (465 aa)
       
 
  0.550
INCA1
Protein INCA1; Inhibitor of CDK, cyclin A1 interacting protein 1; Belongs to the INCA family (236 aa)
           
  0.549
SUPT6H
Transcription elongation factor SPT6; Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H-IWS1-CTD complex r [...] (1726 aa)
           
  0.538
KIAA1191
Putative monooxygenase p33MONOX; Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth; Belongs to the P33MONOX family (305 aa)
           
  0.531
KLHL38
Kelch-like protein 38; Kelch like family member 38; BTB domain containing (581 aa)
           
  0.522
C9orf9
Sperm acrosome-associated protein 9; Chromosome 9 open reading frame 9 (168 aa)
           
  0.522
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (2%) [HD]