node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCL21 | KLHL26 | ENSP00000259607 | ENSP00000300976 | C-C motif chemokine 21; Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4; Belongs to the intercrine beta (chemokine CC) family | Kelch-like protein 26; Kelch like family member 26; BTB domain containing | 0.679 |
CUL3 | KLHL26 | ENSP00000264414 | ENSP00000300976 | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...] | Kelch-like protein 26; Kelch like family member 26; BTB domain containing | 0.491 |
CUL3 | KLHL28 | ENSP00000264414 | ENSP00000379434 | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...] | Kelch-like protein 28; Kelch like family member 28; BTB domain containing | 0.725 |
FBXO18 | KLHL26 | ENSP00000369335 | ENSP00000300976 | F-box DNA helicase 1; 3’-5’ DNA helicase and substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination- promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Also promotes cell death and DNA double-strand breakage in response to replication stress- together with M [...] | Kelch-like protein 26; Kelch like family member 26; BTB domain containing | 0.473 |
FBXO18 | OR2A12 | ENSP00000369335 | ENSP00000386174 | F-box DNA helicase 1; 3’-5’ DNA helicase and substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination- promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Also promotes cell death and DNA double-strand breakage in response to replication stress- together with M [...] | Olfactory receptor 2A12; Odorant receptor; Olfactory receptors, family 2 | 0.440 |
KLHL14 | KLHL26 | ENSP00000352314 | ENSP00000300976 | Kelch-like protein 14; Kelch like family member 14; BTB domain containing | Kelch-like protein 26; Kelch like family member 26; BTB domain containing | 0.550 |
KLHL14 | KLHL28 | ENSP00000352314 | ENSP00000379434 | Kelch-like protein 14; Kelch like family member 14; BTB domain containing | Kelch-like protein 28; Kelch like family member 28; BTB domain containing | 0.823 |
KLHL26 | CCL21 | ENSP00000300976 | ENSP00000259607 | Kelch-like protein 26; Kelch like family member 26; BTB domain containing | C-C motif chemokine 21; Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4; Belongs to the intercrine beta (chemokine CC) family | 0.679 |
KLHL26 | CUL3 | ENSP00000300976 | ENSP00000264414 | Kelch-like protein 26; Kelch like family member 26; BTB domain containing | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...] | 0.491 |
KLHL26 | FBXO18 | ENSP00000300976 | ENSP00000369335 | Kelch-like protein 26; Kelch like family member 26; BTB domain containing | F-box DNA helicase 1; 3’-5’ DNA helicase and substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination- promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Also promotes cell death and DNA double-strand breakage in response to replication stress- together with M [...] | 0.473 |
KLHL26 | KLHL14 | ENSP00000300976 | ENSP00000352314 | Kelch-like protein 26; Kelch like family member 26; BTB domain containing | Kelch-like protein 14; Kelch like family member 14; BTB domain containing | 0.550 |
KLHL26 | KLHL28 | ENSP00000300976 | ENSP00000379434 | Kelch-like protein 26; Kelch like family member 26; BTB domain containing | Kelch-like protein 28; Kelch like family member 28; BTB domain containing | 0.768 |
KLHL26 | NCOA1 | ENSP00000300976 | ENSP00000385216 | Kelch-like protein 26; Kelch like family member 26; BTB domain containing | Nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating mu [...] | 0.490 |
KLHL26 | OR2A12 | ENSP00000300976 | ENSP00000386174 | Kelch-like protein 26; Kelch like family member 26; BTB domain containing | Olfactory receptor 2A12; Odorant receptor; Olfactory receptors, family 2 | 0.709 |
KLHL26 | RNASEH2C | ENSP00000300976 | ENSP00000308193 | Kelch-like protein 26; Kelch like family member 26; BTB domain containing | Ribonuclease H2 subunit C; Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA-RNA duplexes | 0.510 |
KLHL26 | SRRM5 | ENSP00000300976 | ENSP00000476253 | Kelch-like protein 26; Kelch like family member 26; BTB domain containing | Serine/arginine repetitive matrix 5 | 0.643 |
KLHL26 | TRIP13 | ENSP00000300976 | ENSP00000166345 | Kelch-like protein 26; Kelch like family member 26; BTB domain containing | Pachytene checkpoint protein 2 homolog; Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for [...] | 0.430 |
KLHL28 | CUL3 | ENSP00000379434 | ENSP00000264414 | Kelch-like protein 28; Kelch like family member 28; BTB domain containing | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...] | 0.725 |
KLHL28 | KLHL14 | ENSP00000379434 | ENSP00000352314 | Kelch-like protein 28; Kelch like family member 28; BTB domain containing | Kelch-like protein 14; Kelch like family member 14; BTB domain containing | 0.823 |
KLHL28 | KLHL26 | ENSP00000379434 | ENSP00000300976 | Kelch-like protein 28; Kelch like family member 28; BTB domain containing | Kelch-like protein 26; Kelch like family member 26; BTB domain containing | 0.768 |