| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BCAS3 | USP32 | ENSP00000375067 | ENSP00000300896 | Breast carcinoma-amplified sequence 3; Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin; Belongs to the BCAS3 family | Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family | 0.553 |
| ENSG00000274611 | USP32 | ENSP00000478683 | ENSP00000300896 | TBC1 domain family, member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 | Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family | 0.912 |
| ENSG00000278599 | USP32 | ENSP00000483965 | ENSP00000300896 | TBC1 domain family member 3E; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) | Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family | 0.735 |
| IGF2R | USP32 | ENSP00000349437 | ENSP00000300896 | Cation-independent mannose-6-phosphate receptor; Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4; CD molecules | Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family | 0.536 |
| IQCG | USP32 | ENSP00000265239 | ENSP00000300896 | IQ domain-containing protein G; Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin- dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades (Probable). Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility | Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family | 0.607 |
| SIAH1 | SIAH2 | ENSP00000349156 | ENSP00000322457 | E3 ubiquitin-protein ligase SIAH1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription [...] | E3 ubiquitin-protein ligase SIAH2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription [...] | 0.986 |
| SIAH1 | USP32 | ENSP00000349156 | ENSP00000300896 | E3 ubiquitin-protein ligase SIAH1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription [...] | Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family | 0.566 |
| SIAH2 | SIAH1 | ENSP00000322457 | ENSP00000349156 | E3 ubiquitin-protein ligase SIAH2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription [...] | E3 ubiquitin-protein ligase SIAH1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription [...] | 0.986 |
| SIAH2 | USP32 | ENSP00000322457 | ENSP00000300896 | E3 ubiquitin-protein ligase SIAH2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription [...] | Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family | 0.566 |
| TBC1D3A | USP32 | ENSP00000482345 | ENSP00000300896 | TBC1 domain family member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 | Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family | 0.897 |
| TBC1D3B | USP32 | ENSP00000484556 | ENSP00000300896 | TBC1 domain family member 3B; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) | Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family | 0.543 |
| TBC1D3D | USP32 | ENSP00000478426 | ENSP00000300896 | TBC1 domain family member 3D; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) | Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family | 0.912 |
| USP32 | BCAS3 | ENSP00000300896 | ENSP00000375067 | Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family | Breast carcinoma-amplified sequence 3; Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin; Belongs to the BCAS3 family | 0.553 |
| USP32 | ENSG00000274611 | ENSP00000300896 | ENSP00000478683 | Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family | TBC1 domain family, member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 | 0.912 |
| USP32 | ENSG00000278599 | ENSP00000300896 | ENSP00000483965 | Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family | TBC1 domain family member 3E; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) | 0.735 |
| USP32 | IGF2R | ENSP00000300896 | ENSP00000349437 | Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family | Cation-independent mannose-6-phosphate receptor; Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4; CD molecules | 0.536 |
| USP32 | IQCG | ENSP00000300896 | ENSP00000265239 | Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family | IQ domain-containing protein G; Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin- dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades (Probable). Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility | 0.607 |
| USP32 | SIAH1 | ENSP00000300896 | ENSP00000349156 | Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family | E3 ubiquitin-protein ligase SIAH1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription [...] | 0.566 |
| USP32 | SIAH2 | ENSP00000300896 | ENSP00000322457 | Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family | E3 ubiquitin-protein ligase SIAH2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription [...] | 0.566 |
| USP32 | TBC1D3A | ENSP00000300896 | ENSP00000482345 | Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family | TBC1 domain family member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 | 0.897 |
