HDHD2 protein (human) - STRING database

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HDHD2

Haloacid dehalogenase like hydrolase domain containing 2 (259 aa)

Predicted Functional Partners:

IER3IP1

0.792

SKOR2

0.703

TBC1D12

0.682

DCTN5

0.661

ST8SIA5

0.656

NOC3L

0.654

TMED4

0.646

LSM14A

0.628

TTC38

0.615

TCOF1

0.598

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DCTN5	HDHD2	ENSP00000300087	ENSP00000300605	Dynactin subunit 5; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily	Haloacid dehalogenase like hydrolase domain containing 2	0.661
HDHD2	DCTN5	ENSP00000300605	ENSP00000300087	Haloacid dehalogenase like hydrolase domain containing 2	Dynactin subunit 5; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily	0.661
HDHD2	IER3IP1	ENSP00000300605	ENSP00000256433	Haloacid dehalogenase like hydrolase domain containing 2	Immediate early response 3-interacting protein 1; May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By similarity)	0.792
HDHD2	LSM14A	ENSP00000300605	ENSP00000446271	Haloacid dehalogenase like hydrolase domain containing 2	Protein LSM14 homolog A; Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs; LSm proteins	0.628
HDHD2	NOC3L	ENSP00000300605	ENSP00000360412	Haloacid dehalogenase like hydrolase domain containing 2	Nucleolar complex protein 3 homolog; May be required for adipogenesis; Armadillo-like helical domain containing	0.654
HDHD2	SKOR2	ENSP00000300605	ENSP00000483333	Haloacid dehalogenase like hydrolase domain containing 2	SKI family transcriptional corepressor 2; Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system; SKI transcriptional corepressors	0.703
HDHD2	ST8SIA5	ENSP00000300605	ENSP00000321343	Haloacid dehalogenase like hydrolase domain containing 2	Alpha-2,8-sialyltransferase 8E; May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively; Belongs to the glycosyltransferase 29 family	0.656
HDHD2	TBC1D12	ENSP00000300605	ENSP00000225235	Haloacid dehalogenase like hydrolase domain containing 2	TBC1 domain family member 12; May act as a GTPase-activating protein for Rab family protein(s)	0.682
HDHD2	TCOF1	ENSP00000300605	ENSP00000367028	Haloacid dehalogenase like hydrolase domain containing 2	Treacle protein; Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification- following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification	0.598
HDHD2	TMED4	ENSP00000300605	ENSP00000404042	Haloacid dehalogenase like hydrolase domain containing 2	Transmembrane emp24 domain-containing protein 4; Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity); Transmembrane p24 trafficking proteins	0.646
HDHD2	TTC38	ENSP00000300605	ENSP00000370419	Haloacid dehalogenase like hydrolase domain containing 2	Tetratricopeptide repeat domain containing; Belongs to the TTC38 family	0.615
IER3IP1	HDHD2	ENSP00000256433	ENSP00000300605	Immediate early response 3-interacting protein 1; May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By similarity)	Haloacid dehalogenase like hydrolase domain containing 2	0.792
IER3IP1	SKOR2	ENSP00000256433	ENSP00000483333	Immediate early response 3-interacting protein 1; May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By similarity)	SKI family transcriptional corepressor 2; Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system; SKI transcriptional corepressors	0.428
IER3IP1	ST8SIA5	ENSP00000256433	ENSP00000321343	Immediate early response 3-interacting protein 1; May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By similarity)	Alpha-2,8-sialyltransferase 8E; May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively; Belongs to the glycosyltransferase 29 family	0.411
IER3IP1	TCOF1	ENSP00000256433	ENSP00000367028	Immediate early response 3-interacting protein 1; May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By similarity)	Treacle protein; Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification- following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification	0.428
LSM14A	HDHD2	ENSP00000446271	ENSP00000300605	Protein LSM14 homolog A; Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs; LSm proteins	Haloacid dehalogenase like hydrolase domain containing 2	0.628
NOC3L	HDHD2	ENSP00000360412	ENSP00000300605	Nucleolar complex protein 3 homolog; May be required for adipogenesis; Armadillo-like helical domain containing	Haloacid dehalogenase like hydrolase domain containing 2	0.654
NOC3L	SKOR2	ENSP00000360412	ENSP00000483333	Nucleolar complex protein 3 homolog; May be required for adipogenesis; Armadillo-like helical domain containing	SKI family transcriptional corepressor 2; Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system; SKI transcriptional corepressors	0.539
NOC3L	ST8SIA5	ENSP00000360412	ENSP00000321343	Nucleolar complex protein 3 homolog; May be required for adipogenesis; Armadillo-like helical domain containing	Alpha-2,8-sialyltransferase 8E; May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively; Belongs to the glycosyltransferase 29 family	0.501
NOC3L	TBC1D12	ENSP00000360412	ENSP00000225235	Nucleolar complex protein 3 homolog; May be required for adipogenesis; Armadillo-like helical domain containing	TBC1 domain family member 12; May act as a GTPase-activating protein for Rab family protein(s)	0.523

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