node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AP1S1 | C7orf43 | ENSP00000336666 | ENSP00000324741 | AP-1 complex subunit sigma-1A; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | Uncharacterized protein C7orf43; Chromosome 7 open reading frame 43 | 0.737 |
AP1S1 | MAML2 | ENSP00000336666 | ENSP00000434552 | AP-1 complex subunit sigma-1A; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | Mastermind-like protein 2; Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3; Belongs to the mastermind family | 0.443 |
AP1S1 | NAT16 | ENSP00000336666 | ENSP00000300303 | AP-1 complex subunit sigma-1A; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | Probable N-acetyltransferase 16; Probable N-acetyltransferase. Shows only trace activity toward L-His and no N-acetyltransferase activity toward other amino acids. The physiological substrate of this enzyme is unknown; GCN5 related N-acetyltransferases | 0.784 |
C7orf43 | AP1S1 | ENSP00000324741 | ENSP00000336666 | Uncharacterized protein C7orf43; Chromosome 7 open reading frame 43 | AP-1 complex subunit sigma-1A; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | 0.737 |
C7orf43 | CENPN | ENSP00000324741 | ENSP00000377007 | Uncharacterized protein C7orf43; Chromosome 7 open reading frame 43 | Centromere protein N; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes o [...] | 0.443 |
C7orf43 | GAL3ST2 | ENSP00000324741 | ENSP00000192314 | Uncharacterized protein C7orf43; Chromosome 7 open reading frame 43 | Galactose-3-O-sulfotransferase 2; Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal- beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency; Sulfotransferases, membrane bound | 0.529 |
C7orf43 | GAL3ST4 | ENSP00000324741 | ENSP00000353142 | Uncharacterized protein C7orf43; Chromosome 7 open reading frame 43 | Galactose-3-O-sulfotransferase 4; Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc; Sulfotransferases, membrane bound | 0.529 |
C7orf43 | MAML2 | ENSP00000324741 | ENSP00000434552 | Uncharacterized protein C7orf43; Chromosome 7 open reading frame 43 | Mastermind-like protein 2; Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3; Belongs to the mastermind family | 0.644 |
C7orf43 | NAT16 | ENSP00000324741 | ENSP00000300303 | Uncharacterized protein C7orf43; Chromosome 7 open reading frame 43 | Probable N-acetyltransferase 16; Probable N-acetyltransferase. Shows only trace activity toward L-His and no N-acetyltransferase activity toward other amino acids. The physiological substrate of this enzyme is unknown; GCN5 related N-acetyltransferases | 0.856 |
C7orf43 | ZAN | ENSP00000324741 | ENSP00000480750 | Uncharacterized protein C7orf43; Chromosome 7 open reading frame 43 | Zonadhesin; Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling | 0.596 |
CENPN | C7orf43 | ENSP00000377007 | ENSP00000324741 | Centromere protein N; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes o [...] | Uncharacterized protein C7orf43; Chromosome 7 open reading frame 43 | 0.443 |
CENPN | NAT16 | ENSP00000377007 | ENSP00000300303 | Centromere protein N; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes o [...] | Probable N-acetyltransferase 16; Probable N-acetyltransferase. Shows only trace activity toward L-His and no N-acetyltransferase activity toward other amino acids. The physiological substrate of this enzyme is unknown; GCN5 related N-acetyltransferases | 0.443 |
GAL3ST2 | C7orf43 | ENSP00000192314 | ENSP00000324741 | Galactose-3-O-sulfotransferase 2; Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal- beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency; Sulfotransferases, membrane bound | Uncharacterized protein C7orf43; Chromosome 7 open reading frame 43 | 0.529 |
GAL3ST2 | MAML2 | ENSP00000192314 | ENSP00000434552 | Galactose-3-O-sulfotransferase 2; Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal- beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency; Sulfotransferases, membrane bound | Mastermind-like protein 2; Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3; Belongs to the mastermind family | 0.525 |
GAL3ST2 | NAT16 | ENSP00000192314 | ENSP00000300303 | Galactose-3-O-sulfotransferase 2; Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal- beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency; Sulfotransferases, membrane bound | Probable N-acetyltransferase 16; Probable N-acetyltransferase. Shows only trace activity toward L-His and no N-acetyltransferase activity toward other amino acids. The physiological substrate of this enzyme is unknown; GCN5 related N-acetyltransferases | 0.527 |
GAL3ST4 | C7orf43 | ENSP00000353142 | ENSP00000324741 | Galactose-3-O-sulfotransferase 4; Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc; Sulfotransferases, membrane bound | Uncharacterized protein C7orf43; Chromosome 7 open reading frame 43 | 0.529 |
GAL3ST4 | MAML2 | ENSP00000353142 | ENSP00000434552 | Galactose-3-O-sulfotransferase 4; Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc; Sulfotransferases, membrane bound | Mastermind-like protein 2; Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3; Belongs to the mastermind family | 0.525 |
GAL3ST4 | NAT16 | ENSP00000353142 | ENSP00000300303 | Galactose-3-O-sulfotransferase 4; Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc; Sulfotransferases, membrane bound | Probable N-acetyltransferase 16; Probable N-acetyltransferase. Shows only trace activity toward L-His and no N-acetyltransferase activity toward other amino acids. The physiological substrate of this enzyme is unknown; GCN5 related N-acetyltransferases | 0.527 |
MAML2 | AP1S1 | ENSP00000434552 | ENSP00000336666 | Mastermind-like protein 2; Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3; Belongs to the mastermind family | AP-1 complex subunit sigma-1A; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | 0.443 |
MAML2 | C7orf43 | ENSP00000434552 | ENSP00000324741 | Mastermind-like protein 2; Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3; Belongs to the mastermind family | Uncharacterized protein C7orf43; Chromosome 7 open reading frame 43 | 0.644 |