| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADAM10 | TSC22D4 | ENSP00000260408 | ENSP00000300181 | Disintegrin and metalloproteinase domain-containing protein 10; Cleaves the membrane-bound precursor of TNF-alpha at ’76-Ala-|-Val-77’ to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cle [...] | TSC22 domain family protein 4; Transcriptional repressor | 0.705 |
| C6orf47 | TSC22D4 | ENSP00000365076 | ENSP00000300181 | Uncharacterized protein C6orf47; Chromosome 6 open reading frame 47 | TSC22 domain family protein 4; Transcriptional repressor | 0.714 |
| C7orf61 | TSC22D4 | ENSP00000327732 | ENSP00000300181 | Uncharacterized protein C7orf61; Chromosome 7 open reading frame 61 | TSC22 domain family protein 4; Transcriptional repressor | 0.829 |
| FAM117B | NRBP1 | ENSP00000376071 | ENSP00000233557 | Protein FAM117B; Family with sequence similarity 117 member B | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | 0.795 |
| FAM117B | TSC22D2 | ENSP00000376071 | ENSP00000354543 | Protein FAM117B; Family with sequence similarity 117 member B | TSC22 domain family member 2 | 0.821 |
| FAM117B | TSC22D3 | ENSP00000376071 | ENSP00000361458 | Protein FAM117B; Family with sequence similarity 117 member B | TSC22 domain family protein 3; Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti- myogenic effects of glucocorticoids by binding and regulat [...] | 0.804 |
| FAM117B | TSC22D4 | ENSP00000376071 | ENSP00000300181 | Protein FAM117B; Family with sequence similarity 117 member B | TSC22 domain family protein 4; Transcriptional repressor | 0.712 |
| GIGYF1 | TSC22D4 | ENSP00000275732 | ENSP00000300181 | GRB10-interacting GYF protein 1; May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity); Belongs to the GIGYF family | TSC22 domain family protein 4; Transcriptional repressor | 0.736 |
| LHX4 | TSC22D1 | ENSP00000263726 | ENSP00000397435 | LIM/homeobox protein Lhx4; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung; LIM class homeoboxes | TSC22 domain family protein 1; Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter | 0.627 |
| LHX4 | TSC22D2 | ENSP00000263726 | ENSP00000354543 | LIM/homeobox protein Lhx4; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung; LIM class homeoboxes | TSC22 domain family member 2 | 0.711 |
| LHX4 | TSC22D3 | ENSP00000263726 | ENSP00000361458 | LIM/homeobox protein Lhx4; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung; LIM class homeoboxes | TSC22 domain family protein 3; Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti- myogenic effects of glucocorticoids by binding and regulat [...] | 0.526 |
| LHX4 | TSC22D4 | ENSP00000263726 | ENSP00000300181 | LIM/homeobox protein Lhx4; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung; LIM class homeoboxes | TSC22 domain family protein 4; Transcriptional repressor | 0.740 |
| NRBP1 | FAM117B | ENSP00000233557 | ENSP00000376071 | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | Protein FAM117B; Family with sequence similarity 117 member B | 0.795 |
| NRBP1 | TSC22D1 | ENSP00000233557 | ENSP00000397435 | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | TSC22 domain family protein 1; Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter | 0.502 |
| NRBP1 | TSC22D2 | ENSP00000233557 | ENSP00000354543 | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | TSC22 domain family member 2 | 0.719 |
| NRBP1 | TSC22D3 | ENSP00000233557 | ENSP00000361458 | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | TSC22 domain family protein 3; Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti- myogenic effects of glucocorticoids by binding and regulat [...] | 0.837 |
| NRBP1 | TSC22D4 | ENSP00000233557 | ENSP00000300181 | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | TSC22 domain family protein 4; Transcriptional repressor | 0.825 |
| TSC22D1 | LHX4 | ENSP00000397435 | ENSP00000263726 | TSC22 domain family protein 1; Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter | LIM/homeobox protein Lhx4; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung; LIM class homeoboxes | 0.627 |
| TSC22D1 | NRBP1 | ENSP00000397435 | ENSP00000233557 | TSC22 domain family protein 1; Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | 0.502 |
| TSC22D1 | TSC22D3 | ENSP00000397435 | ENSP00000361458 | TSC22 domain family protein 1; Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter | TSC22 domain family protein 3; Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti- myogenic effects of glucocorticoids by binding and regulat [...] | 0.845 |
