node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTR1A | ACTR1B | ENSP00000358921 | ENSP00000289228 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | 0.985 |
ACTR1A | C16orf45 | ENSP00000358921 | ENSP00000300006 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | Uncharacterized protein C16orf45; Chromosome 16 open reading frame 45 | 0.692 |
ACTR1A | DCTN1 | ENSP00000358921 | ENSP00000354791 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. C [...] | 0.998 |
ACTR1A | DCTN4 | ENSP00000358921 | ENSP00000414906 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton | 0.996 |
ACTR1A | DCTN6 | ENSP00000358921 | ENSP00000221114 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | Dynactin subunit 6; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily | 0.999 |
ACTR1B | ACTR1A | ENSP00000289228 | ENSP00000358921 | Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | 0.985 |
ACTR1B | C16orf45 | ENSP00000289228 | ENSP00000300006 | Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | Uncharacterized protein C16orf45; Chromosome 16 open reading frame 45 | 0.801 |
ACTR1B | DCTN1 | ENSP00000289228 | ENSP00000354791 | Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. C [...] | 0.998 |
ACTR1B | DCTN4 | ENSP00000289228 | ENSP00000414906 | Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton | 0.996 |
ACTR1B | DCTN6 | ENSP00000289228 | ENSP00000221114 | Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | Dynactin subunit 6; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily | 0.997 |
C16orf45 | ACTR1A | ENSP00000300006 | ENSP00000358921 | Uncharacterized protein C16orf45; Chromosome 16 open reading frame 45 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | 0.692 |
C16orf45 | ACTR1B | ENSP00000300006 | ENSP00000289228 | Uncharacterized protein C16orf45; Chromosome 16 open reading frame 45 | Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | 0.801 |
C16orf45 | DCTN1 | ENSP00000300006 | ENSP00000354791 | Uncharacterized protein C16orf45; Chromosome 16 open reading frame 45 | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. C [...] | 0.708 |
C16orf45 | DCTN4 | ENSP00000300006 | ENSP00000414906 | Uncharacterized protein C16orf45; Chromosome 16 open reading frame 45 | Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton | 0.797 |
C16orf45 | DCTN6 | ENSP00000300006 | ENSP00000221114 | Uncharacterized protein C16orf45; Chromosome 16 open reading frame 45 | Dynactin subunit 6; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily | 0.794 |
C16orf45 | FOPNL | ENSP00000300006 | ENSP00000255759 | Uncharacterized protein C16orf45; Chromosome 16 open reading frame 45 | LisH domain-containing protein FOPNL; Involved in the biogenesis of cilia. Required for the recruitement of PLK1 to centrosomes and S phase progression | 0.795 |
C16orf45 | KIAA0430 | ENSP00000300006 | ENSP00000379654 | Uncharacterized protein C16orf45; Chromosome 16 open reading frame 45 | Meiosis regulator and mRNA stability factor 1; Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity) | 0.745 |
C16orf45 | NMRK2 | ENSP00000300006 | ENSP00000480091 | Uncharacterized protein C16orf45; Chromosome 16 open reading frame 45 | Nicotinamide riboside kinase 2; Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis; Belongs to the uridine kinase family. NRK subfamily | 0.678 |
C16orf45 | POLK | ENSP00000300006 | ENSP00000241436 | Uncharacterized protein C16orf45; Chromosome 16 open reading frame 45 | DNA polymerase kappa; DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3’-5’ proofreading exonuclease activity. Forms a Schiff base with 5’-deoxyribose phosphate at abasic sites, but does not have lyase activity | 0.701 |
C16orf45 | SDHB | ENSP00000300006 | ENSP00000364649 | Uncharacterized protein C16orf45; Chromosome 16 open reading frame 45 | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) | 0.700 |