CASC4 protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CASC4

Protein CASC4; Cancer susceptibility 4; Belongs to the GOLM1/CASC4 family (436 aa)

Predicted Functional Partners:

MSH5

0.757

CASC1

0.620

EXOC1

0.598

CASC3

0.589

TBC1D25

0.579

PCNX

0.557

B3GNT7

0.539

SUPT3H

0.502

TTC7B

0.497

KCNK13

0.494

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B3GNT7	CASC4	ENSP00000287590	ENSP00000299957	UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 7; May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratan sulfate-related glycans. May play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues; Beta 3-glycosyltransferases	Protein CASC4; Cancer susceptibility 4; Belongs to the GOLM1/CASC4 family	0.539
CASC1	CASC3	ENSP00000379310	ENSP00000264645	Protein phosphatase 1 regulatory subunits	Protein CASC3; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downs [...]	0.566
CASC1	CASC4	ENSP00000379310	ENSP00000299957	Protein phosphatase 1 regulatory subunits	Protein CASC4; Cancer susceptibility 4; Belongs to the GOLM1/CASC4 family	0.620
CASC1	EXOC1	ENSP00000379310	ENSP00000370695	Protein phosphatase 1 regulatory subunits	Exocyst complex component 1; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane	0.590
CASC3	CASC1	ENSP00000264645	ENSP00000379310	Protein CASC3; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downs [...]	Protein phosphatase 1 regulatory subunits	0.566
CASC3	CASC4	ENSP00000264645	ENSP00000299957	Protein CASC3; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downs [...]	Protein CASC4; Cancer susceptibility 4; Belongs to the GOLM1/CASC4 family	0.589
CASC3	EXOC1	ENSP00000264645	ENSP00000370695	Protein CASC3; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downs [...]	Exocyst complex component 1; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane	0.463
CASC4	B3GNT7	ENSP00000299957	ENSP00000287590	Protein CASC4; Cancer susceptibility 4; Belongs to the GOLM1/CASC4 family	UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 7; May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratan sulfate-related glycans. May play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues; Beta 3-glycosyltransferases	0.539
CASC4	CASC1	ENSP00000299957	ENSP00000379310	Protein CASC4; Cancer susceptibility 4; Belongs to the GOLM1/CASC4 family	Protein phosphatase 1 regulatory subunits	0.620
CASC4	CASC3	ENSP00000299957	ENSP00000264645	Protein CASC4; Cancer susceptibility 4; Belongs to the GOLM1/CASC4 family	Protein CASC3; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downs [...]	0.589
CASC4	EXOC1	ENSP00000299957	ENSP00000370695	Protein CASC4; Cancer susceptibility 4; Belongs to the GOLM1/CASC4 family	Exocyst complex component 1; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane	0.598
CASC4	KCNK13	ENSP00000299957	ENSP00000282146	Protein CASC4; Cancer susceptibility 4; Belongs to the GOLM1/CASC4 family	Potassium channel subfamily K member 13; Potassium channel displaying weak inward rectification in symmetrical K(+) solution; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family	0.494
CASC4	MSH5	ENSP00000299957	ENSP00000364855	Protein CASC4; Cancer susceptibility 4; Belongs to the GOLM1/CASC4 family	MutS protein homolog 5; Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity); Belongs to the DNA mismatch repair MutS family	0.757
CASC4	PCNX	ENSP00000299957	ENSP00000304192	Protein CASC4; Cancer susceptibility 4; Belongs to the GOLM1/CASC4 family	Pecanex-like protein 1; Pecanex homolog (Drosophila); Belongs to the pecanex family	0.557
CASC4	SUPT3H	ENSP00000299957	ENSP00000360515	Protein CASC4; Cancer susceptibility 4; Belongs to the GOLM1/CASC4 family	Transcription initiation protein SPT3 homolog; Probable transcriptional activator; SAGA complex	0.502
CASC4	TBC1D25	ENSP00000299957	ENSP00000365962	Protein CASC4; Cancer susceptibility 4; Belongs to the GOLM1/CASC4 family	TBC1 domain family member 25; Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes	0.579
CASC4	TTC7B	ENSP00000299957	ENSP00000336127	Protein CASC4; Cancer susceptibility 4; Belongs to the GOLM1/CASC4 family	Tetratricopeptide repeat protein 7B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions	0.497
EXOC1	CASC1	ENSP00000370695	ENSP00000379310	Exocyst complex component 1; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane	Protein phosphatase 1 regulatory subunits	0.590
EXOC1	CASC3	ENSP00000370695	ENSP00000264645	Exocyst complex component 1; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane	Protein CASC3; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downs [...]	0.463
EXOC1	CASC4	ENSP00000370695	ENSP00000299957	Exocyst complex component 1; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane	Protein CASC4; Cancer susceptibility 4; Belongs to the GOLM1/CASC4 family	0.598

page 1 of 2

Network

Cooccurrence

Experiments

Coexpression

Textmining

Neighborhood

Databases

Fusion

© STRING Consortium 2020

Credits

Access

Info

About