TMPRSS5 protein (human) - STRING database

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TMPRSS5

Transmembrane protease serine 5; May play a role in hearing; Belongs to the peptidase S1 family (457 aa)

Predicted Functional Partners:

TMEM72

0.552

SCGB1C2

0.551

SCGB1C1

0.551

PCDH11X

0.500

NCK1

0.499

HSPA5

0.480

SPINT1

0.420

HFE2

0.409

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HFE2	TMPRSS5	ENSP00000337014	ENSP00000299882	Hemojuvelin; Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis; Belongs to the repulsive guidance molecule (RGM) family	Transmembrane protease serine 5; May play a role in hearing; Belongs to the peptidase S1 family	0.409
HSPA5	NCK1	ENSP00000324173	ENSP00000417273	78 kDa glucose-regulated protein; Plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate (By similarity); Belongs to the heat shock protein 70 family	Cytoplasmic protein NCK1; Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in ce [...]	0.522
HSPA5	TMPRSS5	ENSP00000324173	ENSP00000299882	78 kDa glucose-regulated protein; Plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate (By similarity); Belongs to the heat shock protein 70 family	Transmembrane protease serine 5; May play a role in hearing; Belongs to the peptidase S1 family	0.480
NCK1	HSPA5	ENSP00000417273	ENSP00000324173	Cytoplasmic protein NCK1; Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in ce [...]	78 kDa glucose-regulated protein; Plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate (By similarity); Belongs to the heat shock protein 70 family	0.522
NCK1	TMPRSS5	ENSP00000417273	ENSP00000299882	Cytoplasmic protein NCK1; Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in ce [...]	Transmembrane protease serine 5; May play a role in hearing; Belongs to the peptidase S1 family	0.499
PCDH11X	TMPRSS5	ENSP00000362186	ENSP00000299882	Protocadherin-11 X-linked; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins	Transmembrane protease serine 5; May play a role in hearing; Belongs to the peptidase S1 family	0.500
SCGB1C1	TMEM72	ENSP00000344545	ENSP00000374234	Secretoglobin family 1C member 1; Secretoglobins	Transmembrane protein 72	0.538
SCGB1C1	TMPRSS5	ENSP00000344545	ENSP00000299882	Secretoglobin family 1C member 1; Secretoglobins	Transmembrane protease serine 5; May play a role in hearing; Belongs to the peptidase S1 family	0.551
SCGB1C2	TMEM72	ENSP00000471646	ENSP00000374234	Secretoglobin, family 1C, member 1-like precursor	Transmembrane protein 72	0.538
SCGB1C2	TMPRSS5	ENSP00000471646	ENSP00000299882	Secretoglobin, family 1C, member 1-like precursor	Transmembrane protease serine 5; May play a role in hearing; Belongs to the peptidase S1 family	0.551
SPINT1	TMPRSS5	ENSP00000342098	ENSP00000299882	Kunitz-type protease inhibitor 1; Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14)	Transmembrane protease serine 5; May play a role in hearing; Belongs to the peptidase S1 family	0.420
TMEM72	SCGB1C1	ENSP00000374234	ENSP00000344545	Transmembrane protein 72	Secretoglobin family 1C member 1; Secretoglobins	0.538
TMEM72	SCGB1C2	ENSP00000374234	ENSP00000471646	Transmembrane protein 72	Secretoglobin, family 1C, member 1-like precursor	0.538
TMEM72	TMPRSS5	ENSP00000374234	ENSP00000299882	Transmembrane protein 72	Transmembrane protease serine 5; May play a role in hearing; Belongs to the peptidase S1 family	0.552
TMPRSS5	HFE2	ENSP00000299882	ENSP00000337014	Transmembrane protease serine 5; May play a role in hearing; Belongs to the peptidase S1 family	Hemojuvelin; Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis; Belongs to the repulsive guidance molecule (RGM) family	0.409
TMPRSS5	HSPA5	ENSP00000299882	ENSP00000324173	Transmembrane protease serine 5; May play a role in hearing; Belongs to the peptidase S1 family	78 kDa glucose-regulated protein; Plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate (By similarity); Belongs to the heat shock protein 70 family	0.480
TMPRSS5	NCK1	ENSP00000299882	ENSP00000417273	Transmembrane protease serine 5; May play a role in hearing; Belongs to the peptidase S1 family	Cytoplasmic protein NCK1; Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in ce [...]	0.499
TMPRSS5	PCDH11X	ENSP00000299882	ENSP00000362186	Transmembrane protease serine 5; May play a role in hearing; Belongs to the peptidase S1 family	Protocadherin-11 X-linked; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins	0.500
TMPRSS5	SCGB1C1	ENSP00000299882	ENSP00000344545	Transmembrane protease serine 5; May play a role in hearing; Belongs to the peptidase S1 family	Secretoglobin family 1C member 1; Secretoglobins	0.551
TMPRSS5	SCGB1C2	ENSP00000299882	ENSP00000471646	Transmembrane protease serine 5; May play a role in hearing; Belongs to the peptidase S1 family	Secretoglobin, family 1C, member 1-like precursor	0.551

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