CHRFAM7A protein (human) - STRING database

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CHRFAM7A

CHRNA7-FAM7A fusion protein; CHRNA7 fusion; Belongs to the ligand-gated ion channel (TC 1.A.9) family (412 aa)

Predicted Functional Partners:

OTUD7A

0.807

MTMR10

0.693

HNRNPCL1

0.633

GOLGA8K

0.604

ARHGAP11B

0.581

SLC35F2

0.571

ULK4

0.570

FUS

0.544

DOPEY2

0.522

USE1

0.519

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP11B	CHRFAM7A	ENSP00000481934	ENSP00000299847	Rho GTPase-activating protein 11B; Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Does not possess GTPase activator activity; Rho GTPase activating proteins	CHRNA7-FAM7A fusion protein; CHRNA7 fusion; Belongs to the ligand-gated ion channel (TC 1.A.9) family	0.581
ARHGAP11B	MTMR10	ENSP00000481934	ENSP00000402537	Rho GTPase-activating protein 11B; Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Does not possess GTPase activator activity; Rho GTPase activating proteins	Myotubularin-related protein 10; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential); Myotubularins	0.722
ARHGAP11B	OTUD7A	ENSP00000481934	ENSP00000305926	Rho GTPase-activating protein 11B; Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Does not possess GTPase activator activity; Rho GTPase activating proteins	OTU domain-containing protein 7A; Has deubiquitinating activity towards ’Lys-11’-linked polyubiquitin chains; Belongs to the peptidase C64 family	0.670
CHRFAM7A	ARHGAP11B	ENSP00000299847	ENSP00000481934	CHRNA7-FAM7A fusion protein; CHRNA7 fusion; Belongs to the ligand-gated ion channel (TC 1.A.9) family	Rho GTPase-activating protein 11B; Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Does not possess GTPase activator activity; Rho GTPase activating proteins	0.581
CHRFAM7A	DOPEY2	ENSP00000299847	ENSP00000382104	CHRNA7-FAM7A fusion protein; CHRNA7 fusion; Belongs to the ligand-gated ion channel (TC 1.A.9) family	Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family	0.522
CHRFAM7A	FUS	ENSP00000299847	ENSP00000254108	CHRNA7-FAM7A fusion protein; CHRNA7 fusion; Belongs to the ligand-gated ion channel (TC 1.A.9) family	RNA-binding protein FUS; Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity; Belongs to the RRM TET family	0.544
CHRFAM7A	GOLGA8K	ENSP00000299847	ENSP00000426691	CHRNA7-FAM7A fusion protein; CHRNA7 fusion; Belongs to the ligand-gated ion channel (TC 1.A.9) family	Golgin A8 family member K; Belongs to the GOLGA8 family	0.604
CHRFAM7A	HNRNPCL1	ENSP00000299847	ENSP00000479365	CHRNA7-FAM7A fusion protein; CHRNA7 fusion; Belongs to the ligand-gated ion channel (TC 1.A.9) family	Heterogeneous nuclear ribonucleoprotein C-like 1; May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs; RNA binding motif containing	0.633
CHRFAM7A	MTMR10	ENSP00000299847	ENSP00000402537	CHRNA7-FAM7A fusion protein; CHRNA7 fusion; Belongs to the ligand-gated ion channel (TC 1.A.9) family	Myotubularin-related protein 10; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential); Myotubularins	0.693
CHRFAM7A	OTUD7A	ENSP00000299847	ENSP00000305926	CHRNA7-FAM7A fusion protein; CHRNA7 fusion; Belongs to the ligand-gated ion channel (TC 1.A.9) family	OTU domain-containing protein 7A; Has deubiquitinating activity towards ’Lys-11’-linked polyubiquitin chains; Belongs to the peptidase C64 family	0.807
CHRFAM7A	SLC35F2	ENSP00000299847	ENSP00000436785	CHRNA7-FAM7A fusion protein; CHRNA7 fusion; Belongs to the ligand-gated ion channel (TC 1.A.9) family	Solute carrier family 35 member F2; Putative solute transporter	0.571
CHRFAM7A	ULK4	ENSP00000299847	ENSP00000301831	CHRNA7-FAM7A fusion protein; CHRNA7 fusion; Belongs to the ligand-gated ion channel (TC 1.A.9) family	Serine/threonine-protein kinase ULK4; May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily	0.570
CHRFAM7A	USE1	ENSP00000299847	ENSP00000263897	CHRNA7-FAM7A fusion protein; CHRNA7 fusion; Belongs to the ligand-gated ion channel (TC 1.A.9) family	Vesicle transport protein USE1; SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER; SNAREs	0.519
DOPEY2	CHRFAM7A	ENSP00000382104	ENSP00000299847	Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family	CHRNA7-FAM7A fusion protein; CHRNA7 fusion; Belongs to the ligand-gated ion channel (TC 1.A.9) family	0.522
DOPEY2	HNRNPCL1	ENSP00000382104	ENSP00000479365	Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family	Heterogeneous nuclear ribonucleoprotein C-like 1; May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs; RNA binding motif containing	0.618
DOPEY2	SLC35F2	ENSP00000382104	ENSP00000436785	Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family	Solute carrier family 35 member F2; Putative solute transporter	0.794
FUS	CHRFAM7A	ENSP00000254108	ENSP00000299847	RNA-binding protein FUS; Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity; Belongs to the RRM TET family	CHRNA7-FAM7A fusion protein; CHRNA7 fusion; Belongs to the ligand-gated ion channel (TC 1.A.9) family	0.544
GOLGA8K	CHRFAM7A	ENSP00000426691	ENSP00000299847	Golgin A8 family member K; Belongs to the GOLGA8 family	CHRNA7-FAM7A fusion protein; CHRNA7 fusion; Belongs to the ligand-gated ion channel (TC 1.A.9) family	0.604
HNRNPCL1	CHRFAM7A	ENSP00000479365	ENSP00000299847	Heterogeneous nuclear ribonucleoprotein C-like 1; May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs; RNA binding motif containing	CHRNA7-FAM7A fusion protein; CHRNA7 fusion; Belongs to the ligand-gated ion channel (TC 1.A.9) family	0.633
HNRNPCL1	DOPEY2	ENSP00000479365	ENSP00000382104	Heterogeneous nuclear ribonucleoprotein C-like 1; May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs; RNA binding motif containing	Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family	0.618

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