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  • 11.0 [archived version]
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EMB EMB ERVW-1 ERVW-1 NT5C3A NT5C3A HBZ HBZ INAFM1 INAFM1 CENPV CENPV CD99 CD99 OTOS OTOS FAM192A FAM192A CEBPE CEBPE PSME3 PSME3
"CENPV" - Centromere protein V in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CENPVCentromere protein V; Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis (272 aa)    
Predicted Functional Partners:
HBZ
Hemoglobin subunit zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin (142 aa)
     
   
  0.760
EMB
Embigin; Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity); I-set domain containing (327 aa)
           
  0.738
FAM192A
Protein FAM192A; Family with sequence similarity 192 member A (254 aa)
           
  0.721
ERVW-1
Syncytin-1; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (538 aa)
     
   
  0.675
CD99
CD99 antigen; Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity); Blood group antigens (185 aa)
           
  0.669
CEBPE
CCAAT/enhancer-binding protein epsilon; Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte- myelocyte transition in myeloid differentiation; Belongs to the bZIP family. C/EBP subfamily (281 aa)
           
  0.647
INAFM1
Putative transmembrane protein INAFM1; InaF motif containing 1 (142 aa)
           
  0.636
NT5C3A
Cytosolic 5’-nucleotidase 3A; Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate; Belongs to the pyrimidine 5’-nucleotidase family (336 aa)
           
  0.632
OTOS
Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear (89 aa)
           
  0.621
PSME3
Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] (267 aa)
     
   
  0.617
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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