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  • 11.0 [archived version]
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SERPINE3 SERPINE3 CCDC68 CCDC68 STARD6 STARD6 CPLX4 CPLX4 CPLX3 CPLX3 ELAC1 ELAC1 CPLX1 CPLX1 CPLX2 CPLX2 SNAP25 SNAP25 VAMP1 VAMP1 STX1A STX1A
"CPLX4" - Complexin-4 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CPLX4Complexin-4; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family (160 aa)    
Predicted Functional Partners:
CPLX2
Complexin-2; Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity); Belongs to the complexin/synaphin family (134 aa)
         
  0.927
CPLX1
Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior (134 aa)
     
 
  0.927
CPLX3
Complexin-3; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family (158 aa)
         
0.807
VAMP1
Vesicle-associated membrane protein 1; Involved in the targeting and/or fusion of transport vesicles to their target membrane (118 aa)
           
  0.742
STARD6
StAR-related lipid transfer protein 6; May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity); StAR related lipid transfer domain containing (220 aa)
           
  0.646
STX1A
Syntaxin-1A; Plays a role in hormone and neurotransmitter exocytosis (By similarity). Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)- regulation of exocytosis acrosomal reaction in sperm; Syntaxins (288 aa)
           
  0.640
ELAC1
Zinc phosphodiesterase ELAC protein 1; Zinc phosphodiesterase, which displays some tRNA 3’- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3’-trailer from precursor tRNA; Belongs to the RNase Z family (363 aa)
           
  0.637
SNAP25
Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells; SNAREs (206 aa)
           
  0.607
SERPINE3
Serpin E3; Probable serine protease inhibitor; Serpin peptidase inhibitors (424 aa)
           
  0.601
CCDC68
Coiled-coil domain-containing protein 68; Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells. Together with CCDC120, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (335 aa)
           
  0.561
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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