| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACAD10 | KIAA0319 | ENSP00000389813 | ENSP00000367459 | Acyl-CoA dehydrogenase family member 10; Acyl-CoA dehydrogenase only active with R- and S-2- methyl-C15-CoA | Dyslexia-associated protein KIAA0319; Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non- cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites | 0.402 |
| ACAD10 | MBTPS1 | ENSP00000389813 | ENSP00000344223 | Acyl-CoA dehydrogenase family member 10; Acyl-CoA dehydrogenase only active with R- and S-2- methyl-C15-CoA | Membrane-bound transcription factor site-1 protease; Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg- Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lyso [...] | 0.449 |
| ACAD10 | SLC38A8 | ENSP00000389813 | ENSP00000299709 | Acyl-CoA dehydrogenase family member 10; Acyl-CoA dehydrogenase only active with R- and S-2- methyl-C15-CoA | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter; Belongs to the amino acid/polyamine transporter 2 family | 0.536 |
| FRMD7 | SLC38A8 | ENSP00000298542 | ENSP00000299709 | FERM domain-containing protein 7; Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability; FERM domain containing | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter; Belongs to the amino acid/polyamine transporter 2 family | 0.473 |
| KIAA0319 | ACAD10 | ENSP00000367459 | ENSP00000389813 | Dyslexia-associated protein KIAA0319; Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non- cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites | Acyl-CoA dehydrogenase family member 10; Acyl-CoA dehydrogenase only active with R- and S-2- methyl-C15-CoA | 0.402 |
| KIAA0319 | SLC38A8 | ENSP00000367459 | ENSP00000299709 | Dyslexia-associated protein KIAA0319; Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non- cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter; Belongs to the amino acid/polyamine transporter 2 family | 0.537 |
| LPPR4 | SLC38A8 | ENSP00000359204 | ENSP00000299709 | Phospholipid phosphatase-related protein type 4; Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter; Belongs to the amino acid/polyamine transporter 2 family | 0.624 |
| MBTPS1 | ACAD10 | ENSP00000344223 | ENSP00000389813 | Membrane-bound transcription factor site-1 protease; Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg- Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lyso [...] | Acyl-CoA dehydrogenase family member 10; Acyl-CoA dehydrogenase only active with R- and S-2- methyl-C15-CoA | 0.449 |
| MBTPS1 | SLC38A8 | ENSP00000344223 | ENSP00000299709 | Membrane-bound transcription factor site-1 protease; Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg- Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lyso [...] | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter; Belongs to the amino acid/polyamine transporter 2 family | 0.568 |
| NECAB2 | SLC38A8 | ENSP00000307449 | ENSP00000299709 | N-terminal EF-hand calcium-binding protein 2; May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation; EF-hand domain containing | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter; Belongs to the amino acid/polyamine transporter 2 family | 0.535 |
| SLC25A35 | SLC38A8 | ENSP00000369407 | ENSP00000299709 | Solute carrier family 25 member 35; Belongs to the mitochondrial carrier (TC 2.A.29) family | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter; Belongs to the amino acid/polyamine transporter 2 family | 0.496 |
| SLC38A8 | ACAD10 | ENSP00000299709 | ENSP00000389813 | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter; Belongs to the amino acid/polyamine transporter 2 family | Acyl-CoA dehydrogenase family member 10; Acyl-CoA dehydrogenase only active with R- and S-2- methyl-C15-CoA | 0.536 |
| SLC38A8 | FRMD7 | ENSP00000299709 | ENSP00000298542 | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter; Belongs to the amino acid/polyamine transporter 2 family | FERM domain-containing protein 7; Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability; FERM domain containing | 0.473 |
| SLC38A8 | KIAA0319 | ENSP00000299709 | ENSP00000367459 | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter; Belongs to the amino acid/polyamine transporter 2 family | Dyslexia-associated protein KIAA0319; Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non- cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites | 0.537 |
| SLC38A8 | LPPR4 | ENSP00000299709 | ENSP00000359204 | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter; Belongs to the amino acid/polyamine transporter 2 family | Phospholipid phosphatase-related protein type 4; Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus | 0.624 |
| SLC38A8 | MBTPS1 | ENSP00000299709 | ENSP00000344223 | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter; Belongs to the amino acid/polyamine transporter 2 family | Membrane-bound transcription factor site-1 protease; Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg- Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lyso [...] | 0.568 |
| SLC38A8 | NECAB2 | ENSP00000299709 | ENSP00000307449 | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter; Belongs to the amino acid/polyamine transporter 2 family | N-terminal EF-hand calcium-binding protein 2; May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation; EF-hand domain containing | 0.535 |
| SLC38A8 | SLC25A35 | ENSP00000299709 | ENSP00000369407 | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter; Belongs to the amino acid/polyamine transporter 2 family | Solute carrier family 25 member 35; Belongs to the mitochondrial carrier (TC 2.A.29) family | 0.496 |
| SLC38A8 | SLC38A9 | ENSP00000299709 | ENSP00000380074 | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter; Belongs to the amino acid/polyamine transporter 2 family | Sodium-coupled neutral amino acid transporter 9; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acids. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino a [...] | 0.673 |
| SLC38A8 | SLC6A19 | ENSP00000299709 | ENSP00000305302 | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter; Belongs to the amino acid/polyamine transporter 2 family | Sodium-dependent neutral amino acid transporter B(0)AT1; Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride- independent; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A19 subfamily | 0.546 |
