TK2 protein (human) - STRING database

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TK2

Thymidine kinase 2, mitochondrial; Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents; Belongs to the DCK/DGK family (265 aa)

Predicted Functional Partners:

DUT

0.975

TYMP

0.958

TYMS

0.958

DTYMK

0.943

UPP1

0.938

UPP2

0.932

DCTD

0.931

TK1

0.927

ENTPD3

0.923

ENTPD8

0.921

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DCTD	DTYMK	ENSP00000349576	ENSP00000304802	Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase	Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family	0.976
DCTD	DUT	ENSP00000349576	ENSP00000370376	Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase	Deoxyuridine 5’-triphosphate nucleotidohydrolase, mitochondrial; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family	0.978
DCTD	TK1	ENSP00000349576	ENSP00000301634	Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase	Thymidine kinase, cytosolic; Thymidine kinase 1; Belongs to the thymidine kinase family	0.967
DCTD	TK2	ENSP00000349576	ENSP00000299697	Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase	Thymidine kinase 2, mitochondrial; Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents; Belongs to the DCK/DGK family	0.931
DCTD	TYMP	ENSP00000349576	ENSP00000379038	Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase	Thymidine phosphorylase; May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro; Minor histocompatibility antigens	0.486
DCTD	TYMS	ENSP00000349576	ENSP00000315644	Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase	Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway	0.993
DCTD	UPP1	ENSP00000349576	ENSP00000330032	Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase	Uridine phosphorylase 1; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis; Belongs to the PNP/UDP phosphorylase family	0.521
DCTD	UPP2	ENSP00000349576	ENSP00000474090	Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase	Uridine phosphorylase 2; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(’)-deoxyuridine as substrates	0.447
DTYMK	DCTD	ENSP00000304802	ENSP00000349576	Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family	Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase	0.976
DTYMK	DUT	ENSP00000304802	ENSP00000370376	Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family	Deoxyuridine 5’-triphosphate nucleotidohydrolase, mitochondrial; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family	0.994
DTYMK	ENTPD3	ENSP00000304802	ENSP00000301825	Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family	Ectonucleoside triphosphate diphosphohydrolase 3; Has a threefold preference for the hydrolysis of ATP over ADP	0.925
DTYMK	ENTPD8	ENSP00000304802	ENSP00000360561	Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family	Ectonucleoside triphosphate diphosphohydrolase 8; Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP	0.915
DTYMK	TK1	ENSP00000304802	ENSP00000301634	Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family	Thymidine kinase, cytosolic; Thymidine kinase 1; Belongs to the thymidine kinase family	0.991
DTYMK	TK2	ENSP00000304802	ENSP00000299697	Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family	Thymidine kinase 2, mitochondrial; Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents; Belongs to the DCK/DGK family	0.943
DTYMK	TYMP	ENSP00000304802	ENSP00000379038	Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family	Thymidine phosphorylase; May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro; Minor histocompatibility antigens	0.519
DTYMK	TYMS	ENSP00000304802	ENSP00000315644	Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family	Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway	0.992
DTYMK	UPP1	ENSP00000304802	ENSP00000330032	Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family	Uridine phosphorylase 1; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis; Belongs to the PNP/UDP phosphorylase family	0.416
DUT	DCTD	ENSP00000370376	ENSP00000349576	Deoxyuridine 5’-triphosphate nucleotidohydrolase, mitochondrial; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family	Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase	0.978
DUT	DTYMK	ENSP00000370376	ENSP00000304802	Deoxyuridine 5’-triphosphate nucleotidohydrolase, mitochondrial; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family	Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family	0.994
DUT	TK1	ENSP00000370376	ENSP00000301634	Deoxyuridine 5’-triphosphate nucleotidohydrolase, mitochondrial; This enzyme is involved in nucleotide metabolism- it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family	Thymidine kinase, cytosolic; Thymidine kinase 1; Belongs to the thymidine kinase family	0.965

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