HDGFRP3 protein (human) - STRING database

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HDGFRP3

Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation (203 aa)

Predicted Functional Partners:

POGZ

0.680

TRIP12

0.670

SRRD

0.638

HMCN2

0.634

PON3

0.514

DIDO1

0.498

ZKSCAN8

0.490

CCDC59

0.477

SNN

0.475

BRPF1

0.464

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRPF1	HDGFRP3	ENSP00000373340	ENSP00000299633	Peregrin; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Preferentially mediates histone H3-K23 acetylation. Positively regulates the transcription of RUNX1 and RUNX2; Bromodomain containing	Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation	0.464
CCDC59	HDGFRP3	ENSP00000256151	ENSP00000299633	Thyroid transcription factor 1-associated protein 26; Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities	Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation	0.477
DIDO1	HDGFRP3	ENSP00000266070	ENSP00000299633	Death-inducer obliterator 1; Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development; PHD finger proteins	Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation	0.498
DIDO1	TRIP12	ENSP00000266070	ENSP00000373696	Death-inducer obliterator 1; Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development; PHD finger proteins	E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in [...]	0.817
HDGFRP3	BRPF1	ENSP00000299633	ENSP00000373340	Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation	Peregrin; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Preferentially mediates histone H3-K23 acetylation. Positively regulates the transcription of RUNX1 and RUNX2; Bromodomain containing	0.464
HDGFRP3	CCDC59	ENSP00000299633	ENSP00000256151	Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation	Thyroid transcription factor 1-associated protein 26; Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities	0.477
HDGFRP3	DIDO1	ENSP00000299633	ENSP00000266070	Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation	Death-inducer obliterator 1; Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development; PHD finger proteins	0.498
HDGFRP3	HMCN2	ENSP00000299633	ENSP00000485357	Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation	Hemicentin-2; Immunoglobulin like domain containing; Fibulins	0.634
HDGFRP3	POGZ	ENSP00000299633	ENSP00000271715	Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation	Pogo transposable element with ZNF domain; Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms; DNA transposon derived genes	0.680
HDGFRP3	PON3	ENSP00000299633	ENSP00000265627	Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation	Serum paraoxonase/lactonase 3; Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents; Belongs to the paraoxonase family	0.514
HDGFRP3	SNN	ENSP00000299633	ENSP00000329287	Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation	Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation	0.475
HDGFRP3	SRRD	ENSP00000299633	ENSP00000215917	Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation	SRR1-like protein; May be involved in a circadian clock input pathway	0.638
HDGFRP3	TRIP12	ENSP00000299633	ENSP00000373696	Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation	E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in [...]	0.670
HDGFRP3	ZKSCAN8	ENSP00000299633	ENSP00000332750	Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation	Zinc finger protein with KRAB and SCAN domains 8; May be involved in transcriptional regulation; SCAN domain containing	0.490
HMCN2	HDGFRP3	ENSP00000485357	ENSP00000299633	Hemicentin-2; Immunoglobulin like domain containing; Fibulins	Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation	0.634
HMCN2	PON3	ENSP00000485357	ENSP00000265627	Hemicentin-2; Immunoglobulin like domain containing; Fibulins	Serum paraoxonase/lactonase 3; Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents; Belongs to the paraoxonase family	0.644
HMCN2	SNN	ENSP00000485357	ENSP00000329287	Hemicentin-2; Immunoglobulin like domain containing; Fibulins	Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation	0.564
HMCN2	SRRD	ENSP00000485357	ENSP00000215917	Hemicentin-2; Immunoglobulin like domain containing; Fibulins	SRR1-like protein; May be involved in a circadian clock input pathway	0.661
POGZ	HDGFRP3	ENSP00000271715	ENSP00000299633	Pogo transposable element with ZNF domain; Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms; DNA transposon derived genes	Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation	0.680
POGZ	TRIP12	ENSP00000271715	ENSP00000373696	Pogo transposable element with ZNF domain; Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms; DNA transposon derived genes	E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in [...]	0.471

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