node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSG00000266953 | KIAA0355 | ENSP00000468690 | ENSP00000299505 | Uncharacterized protein | Uncharacterized protein KIAA0355; KIAA0355 | 0.537 |
ENSG00000266953 | MPHOSPH6 | ENSP00000468690 | ENSP00000258169 | Uncharacterized protein | M-phase phosphoprotein 6; RNA-binding protein that associates with the RNA exosome complex. Involved in the 3’-processing of the 7S pre-RNA to the mature 5.8S rRNA and may play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D | 0.428 |
HSD17B2 | KIAA0355 | ENSP00000199936 | ENSP00000299505 | Estradiol 17-beta-dehydrogenase 2; Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH; Short chain dehydrogenase/reductase superfamily | Uncharacterized protein KIAA0355; KIAA0355 | 0.698 |
HSD17B2 | LSM14A | ENSP00000199936 | ENSP00000446271 | Estradiol 17-beta-dehydrogenase 2; Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH; Short chain dehydrogenase/reductase superfamily | Protein LSM14 homolog A; Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs; LSm proteins | 0.649 |
HSD17B2 | MPHOSPH6 | ENSP00000199936 | ENSP00000258169 | Estradiol 17-beta-dehydrogenase 2; Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH; Short chain dehydrogenase/reductase superfamily | M-phase phosphoprotein 6; RNA-binding protein that associates with the RNA exosome complex. Involved in the 3’-processing of the 7S pre-RNA to the mature 5.8S rRNA and may play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D | 0.433 |
HSD17B2 | THAP9 | ENSP00000199936 | ENSP00000305533 | Estradiol 17-beta-dehydrogenase 2; Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH; Short chain dehydrogenase/reductase superfamily | DNA transposase THAP9; Active transposase that specifically recognizes the bipartite 5’-TXXGGGX(A/T)-3’ consensus motif and mediates transposition; THAP domain containing | 0.600 |
HSD17B2 | UBA2 | ENSP00000199936 | ENSP00000246548 | Estradiol 17-beta-dehydrogenase 2; Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH; Short chain dehydrogenase/reductase superfamily | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2; Ubiquitin like modifier activating enzymes | 0.636 |
HSD17B2 | WTIP | ENSP00000199936 | ENSP00000466953 | Estradiol 17-beta-dehydrogenase 2; Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH; Short chain dehydrogenase/reductase superfamily | Wilms tumor protein 1-interacting protein; Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadheri [...] | 0.604 |
KIAA0355 | ENSG00000266953 | ENSP00000299505 | ENSP00000468690 | Uncharacterized protein KIAA0355; KIAA0355 | Uncharacterized protein | 0.537 |
KIAA0355 | HSD17B2 | ENSP00000299505 | ENSP00000199936 | Uncharacterized protein KIAA0355; KIAA0355 | Estradiol 17-beta-dehydrogenase 2; Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH; Short chain dehydrogenase/reductase superfamily | 0.698 |
KIAA0355 | LSM14A | ENSP00000299505 | ENSP00000446271 | Uncharacterized protein KIAA0355; KIAA0355 | Protein LSM14 homolog A; Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs; LSm proteins | 0.725 |
KIAA0355 | MPHOSPH6 | ENSP00000299505 | ENSP00000258169 | Uncharacterized protein KIAA0355; KIAA0355 | M-phase phosphoprotein 6; RNA-binding protein that associates with the RNA exosome complex. Involved in the 3’-processing of the 7S pre-RNA to the mature 5.8S rRNA and may play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D | 0.714 |
KIAA0355 | NCKAP1 | ENSP00000299505 | ENSP00000354251 | Uncharacterized protein KIAA0355; KIAA0355 | Nck-associated protein 1; Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes; Belongs to the HEM-1/HEM-2 family | 0.613 |
KIAA0355 | PDCD2L | ENSP00000299505 | ENSP00000246535 | Uncharacterized protein KIAA0355; KIAA0355 | Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase | 0.537 |
KIAA0355 | RNF219 | ENSP00000299505 | ENSP00000282003 | Uncharacterized protein KIAA0355; KIAA0355 | Ring finger protein 219 | 0.560 |
KIAA0355 | THAP9 | ENSP00000299505 | ENSP00000305533 | Uncharacterized protein KIAA0355; KIAA0355 | DNA transposase THAP9; Active transposase that specifically recognizes the bipartite 5’-TXXGGGX(A/T)-3’ consensus motif and mediates transposition; THAP domain containing | 0.753 |
KIAA0355 | UBA2 | ENSP00000299505 | ENSP00000246548 | Uncharacterized protein KIAA0355; KIAA0355 | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2; Ubiquitin like modifier activating enzymes | 0.695 |
KIAA0355 | WTIP | ENSP00000299505 | ENSP00000466953 | Uncharacterized protein KIAA0355; KIAA0355 | Wilms tumor protein 1-interacting protein; Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadheri [...] | 0.669 |
LSM14A | HSD17B2 | ENSP00000446271 | ENSP00000199936 | Protein LSM14 homolog A; Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs; LSm proteins | Estradiol 17-beta-dehydrogenase 2; Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH; Short chain dehydrogenase/reductase superfamily | 0.649 |
LSM14A | KIAA0355 | ENSP00000446271 | ENSP00000299505 | Protein LSM14 homolog A; Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs; LSm proteins | Uncharacterized protein KIAA0355; KIAA0355 | 0.725 |