POTED protein (human) - STRING database

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

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POTED

POTE ankyrin domain family member D; Belongs to the POTE family (584 aa)

Predicted Functional Partners:

POTEC

0.847

339010

0.821

TMEM105

0.477

CAPZB

0.464

C4orf45

0.448

CAP1

0.441

CAP2

0.441

PFN1

0.440

FMNL1

0.433

WDR90

0.432

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
339010	CAP1	ENSP00000483103	ENSP00000361883	Homo sapiens POTE ankyrin domain family, member B-like (LOC102724631), transcript variant 1, mRNA; Belongs to the POTE family	Adenylyl cyclase-associated protein 1; Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity; Belongs to the CAP family	0.441
339010	CAP2	ENSP00000483103	ENSP00000229922	Homo sapiens POTE ankyrin domain family, member B-like (LOC102724631), transcript variant 1, mRNA; Belongs to the POTE family	Adenylyl cyclase-associated protein 2; May have a regulatory bifunctional role; Belongs to the CAP family	0.441
339010	CAPZB	ENSP00000483103	ENSP00000401010	Homo sapiens POTE ankyrin domain family, member B-like (LOC102724631), transcript variant 1, mRNA; Belongs to the POTE family	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization	0.464
339010	FMNL1	ENSP00000483103	ENSP00000329219	Homo sapiens POTE ankyrin domain family, member B-like (LOC102724631), transcript variant 1, mRNA; Belongs to the POTE family	Formin-like protein 1; May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape; Armadillo-like helical domain containing	0.433
339010	POTEC	ENSP00000483103	ENSP00000351856	Homo sapiens POTE ankyrin domain family, member B-like (LOC102724631), transcript variant 1, mRNA; Belongs to the POTE family	POTE ankyrin domain family member C	0.815
339010	POTED	ENSP00000483103	ENSP00000299443	Homo sapiens POTE ankyrin domain family, member B-like (LOC102724631), transcript variant 1, mRNA; Belongs to the POTE family	POTE ankyrin domain family member D; Belongs to the POTE family	0.821
339010	WDR90	ENSP00000483103	ENSP00000293879	Homo sapiens POTE ankyrin domain family, member B-like (LOC102724631), transcript variant 1, mRNA; Belongs to the POTE family	WD repeat-containing protein 90; WD repeat domain containing	0.432
C4orf45	POTED	ENSP00000412215	ENSP00000299443	Uncharacterized protein C4orf45; Chromosome 4 open reading frame 45	POTE ankyrin domain family member D; Belongs to the POTE family	0.448
CAP1	339010	ENSP00000361883	ENSP00000483103	Adenylyl cyclase-associated protein 1; Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity; Belongs to the CAP family	Homo sapiens POTE ankyrin domain family, member B-like (LOC102724631), transcript variant 1, mRNA; Belongs to the POTE family	0.441
CAP1	CAP2	ENSP00000361883	ENSP00000229922	Adenylyl cyclase-associated protein 1; Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity; Belongs to the CAP family	Adenylyl cyclase-associated protein 2; May have a regulatory bifunctional role; Belongs to the CAP family	0.926
CAP1	CAPZB	ENSP00000361883	ENSP00000401010	Adenylyl cyclase-associated protein 1; Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity; Belongs to the CAP family	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization	0.577
CAP1	FMNL1	ENSP00000361883	ENSP00000329219	Adenylyl cyclase-associated protein 1; Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity; Belongs to the CAP family	Formin-like protein 1; May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape; Armadillo-like helical domain containing	0.419
CAP1	PFN1	ENSP00000361883	ENSP00000225655	Adenylyl cyclase-associated protein 1; Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity; Belongs to the CAP family	Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR	0.695
CAP1	POTEC	ENSP00000361883	ENSP00000351856	Adenylyl cyclase-associated protein 1; Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity; Belongs to the CAP family	POTE ankyrin domain family member C	0.441
CAP1	POTED	ENSP00000361883	ENSP00000299443	Adenylyl cyclase-associated protein 1; Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity; Belongs to the CAP family	POTE ankyrin domain family member D; Belongs to the POTE family	0.441
CAP1	WDR90	ENSP00000361883	ENSP00000293879	Adenylyl cyclase-associated protein 1; Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity; Belongs to the CAP family	WD repeat-containing protein 90; WD repeat domain containing	0.483
CAP2	339010	ENSP00000229922	ENSP00000483103	Adenylyl cyclase-associated protein 2; May have a regulatory bifunctional role; Belongs to the CAP family	Homo sapiens POTE ankyrin domain family, member B-like (LOC102724631), transcript variant 1, mRNA; Belongs to the POTE family	0.441
CAP2	CAP1	ENSP00000229922	ENSP00000361883	Adenylyl cyclase-associated protein 2; May have a regulatory bifunctional role; Belongs to the CAP family	Adenylyl cyclase-associated protein 1; Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity; Belongs to the CAP family	0.926
CAP2	CAPZB	ENSP00000229922	ENSP00000401010	Adenylyl cyclase-associated protein 2; May have a regulatory bifunctional role; Belongs to the CAP family	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization	0.449
CAP2	PFN1	ENSP00000229922	ENSP00000225655	Adenylyl cyclase-associated protein 2; May have a regulatory bifunctional role; Belongs to the CAP family	Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR	0.528

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