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  • 11.0 [archived version]
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UAP1L1 UAP1L1 AFMID AFMID TH TH PAH PAH QDPR QDPR PCBD1 PCBD1 HNF1A HNF1A TPH2 TPH2 PCBD2 PCBD2 TPH1 TPH1 HNF1B HNF1B
"PCBD1" - Pterin-4-alpha-carbinolamine dehydratase in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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PCBD1Pterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity; Belongs to the pterin-4-alpha-carbinolamine dehydratase family (104 aa)    
Predicted Functional Partners:
HNF1A
Hepatocyte nuclear factor 1-alpha; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5’- GTTAATNATTAAC-3’; Belongs to the HNF1 homeobox family (631 aa)
     
 
  0.991
QDPR
Dihydropteridine reductase; The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases; Short chain dehydrogenase/reductase superfamily (244 aa)
     
 
  0.985
PAH
Phenylalanine-4-hydroxylase; Phenylalanine hydroxylase (452 aa)
   
  0.984
UAP1L1
UDP-N-acetylhexosamine pyrophosphorylase-like protein 1; UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 (507 aa)
       
      0.976
TH
Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons; Belongs to the biopterin-dependent aromatic amino acid hydroxylase family (528 aa)
   
 
  0.951
AFMID
Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites (308 aa)
       
 
  0.949
TPH1
Tryptophan hydroxylase 1 (444 aa)
   
 
  0.948
TPH2
Tryptophan hydroxylase 2 (490 aa)
   
 
  0.928
HNF1B
Hepatocyte nuclear factor 1-beta; Transcription factor, probably binds to the inverted palindrome 5’-GTTAATNATTAAC-3’; Belongs to the HNF1 homeobox family (557 aa)
     
 
  0.902
PCBD2
Pterin-4-alpha-carbinolamine dehydratase 2; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity) (130 aa)
   
0.856
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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