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  • 11.0 [archived version]
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RABGGTB RABGGTB CLDN8 CLDN8 LCA5L LCA5L YBEY YBEY TMEM41B TMEM41B CHODL CHODL IGSF5 IGSF5 CCDC3 CCDC3 STAC2 STAC2 HSPB8 HSPB8 GPBP1L1 GPBP1L1
"CHODL" - Chondrolectin in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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CHODLChondrolectin; May play a role in the development of the nervous system such as in neurite outgrowth and elongation. May be involved in motor axon growth and guidance; C-type lectin domain containing (273 aa)    
Predicted Functional Partners:
YBEY
Endoribonuclease YbeY; Single strand-specific metallo-endoribonuclease involved in rRNA maturation (167 aa)
           
  0.745
TMEM41B
Transmembrane protein 41B; Required for normal motor neuron development (291 aa)
           
  0.625
CCDC3
Coiled-coil domain-containing protein 3; Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha- induced NF-kappaB activation in ECs. Positively regulates lipid accumulation in adipose cells (By similarity) (270 aa)
           
  0.564
IGSF5
Immunoglobulin superfamily member 5; Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia- spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells- Sertoli cells (By similarity); Belongs to the immunoglobulin superfamily (407 aa)
           
  0.523
HSPB8
Heat shock protein beta-8; Displays temperature-dependent chaperone activity; Belongs to the small heat shock protein (HSP20) family (196 aa)
           
  0.475
CLDN8
Claudin-8; Tight-junction protein required for paracellular chloride transport in the kidney. Mediates recruitment of CLDN4 to tight junction in the kidney. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity (225 aa)
           
  0.472
STAC2
SH3 and cysteine rich domain 2 (411 aa)
           
  0.462
LCA5L
Lebercilin-like protein; LCA5L, lebercilin like (670 aa)
           
  0.460
GPBP1L1
Vasculin-like protein 1; Possible transcription factor (474 aa)
           
  0.447
RABGGTB
Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A; Belongs to the protein prenyltransferase subunit beta family (331 aa)
       
 
  0.445
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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