| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADAMTS14 | PALD1 | ENSP00000362304 | ENSP00000263563 | A disintegrin and metalloproteinase with thrombospondin motifs 14; Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity; ADAM metallopeptidases with thrombospondin type 1 motif | Paladin; Phosphatase domain containing, paladin 1 | 0.574 |
| ADAMTS14 | TBATA | ENSP00000362304 | ENSP00000299290 | A disintegrin and metalloproteinase with thrombospondin motifs 14; Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity; ADAM metallopeptidases with thrombospondin type 1 motif | Protein TBATA; May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function | 0.531 |
| AKAP14 | MPPED1 | ENSP00000360485 | ENSP00000388137 | A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins | Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro) | 0.660 |
| AKAP14 | TBATA | ENSP00000360485 | ENSP00000299290 | A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins | Protein TBATA; May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function | 0.515 |
| CKAP2L | DENND3 | ENSP00000305204 | ENSP00000262585 | Cytoskeleton-associated protein 2-like; Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells | DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...] | 0.553 |
| CKAP2L | NCLN | ENSP00000305204 | ENSP00000246117 | Cytoskeleton-associated protein 2-like; Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning; Belongs to the nicastrin family | 0.534 |
| CKAP2L | TBATA | ENSP00000305204 | ENSP00000299290 | Cytoskeleton-associated protein 2-like; Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells | Protein TBATA; May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function | 0.533 |
| CKAP2L | VEZF1 | ENSP00000305204 | ENSP00000462337 | Cytoskeleton-associated protein 2-like; Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells | Vascular endothelial zinc finger 1; Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3; Zinc fingers C2H2-type | 0.446 |
| DENND3 | CKAP2L | ENSP00000262585 | ENSP00000305204 | DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...] | Cytoskeleton-associated protein 2-like; Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells | 0.553 |
| DENND3 | NCLN | ENSP00000262585 | ENSP00000246117 | DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...] | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning; Belongs to the nicastrin family | 0.594 |
| DENND3 | TBATA | ENSP00000262585 | ENSP00000299290 | DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...] | Protein TBATA; May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function | 0.561 |
| DENND3 | VEZF1 | ENSP00000262585 | ENSP00000462337 | DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...] | Vascular endothelial zinc finger 1; Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3; Zinc fingers C2H2-type | 0.485 |
| INCA1 | TBATA | ENSP00000458316 | ENSP00000299290 | Protein INCA1; Inhibitor of CDK, cyclin A1 interacting protein 1; Belongs to the INCA family | Protein TBATA; May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function | 0.644 |
| MPPED1 | AKAP14 | ENSP00000388137 | ENSP00000360485 | Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro) | A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins | 0.660 |
| MPPED1 | TBATA | ENSP00000388137 | ENSP00000299290 | Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro) | Protein TBATA; May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function | 0.515 |
| NCLN | CKAP2L | ENSP00000246117 | ENSP00000305204 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning; Belongs to the nicastrin family | Cytoskeleton-associated protein 2-like; Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells | 0.534 |
| NCLN | DENND3 | ENSP00000246117 | ENSP00000262585 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning; Belongs to the nicastrin family | DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...] | 0.594 |
| NCLN | TBATA | ENSP00000246117 | ENSP00000299290 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning; Belongs to the nicastrin family | Protein TBATA; May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function | 0.649 |
| NCLN | VEZF1 | ENSP00000246117 | ENSP00000462337 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning; Belongs to the nicastrin family | Vascular endothelial zinc finger 1; Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3; Zinc fingers C2H2-type | 0.531 |
| PALD1 | ADAMTS14 | ENSP00000263563 | ENSP00000362304 | Paladin; Phosphatase domain containing, paladin 1 | A disintegrin and metalloproteinase with thrombospondin motifs 14; Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity; ADAM metallopeptidases with thrombospondin type 1 motif | 0.574 |
