| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APAF1 | IKBIP | ENSP00000448165 | ENSP00000299157 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis; Apoptosome | IKBKB interacting protein | 0.536 |
| ARFGAP3 | CLTB | ENSP00000263245 | ENSP00000309415 | ADP-ribosylation factor GTPase-activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes; ArfGAPs | Clathrin light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family | 0.923 |
| ARFGAP3 | IKBIP | ENSP00000263245 | ENSP00000299157 | ADP-ribosylation factor GTPase-activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes; ArfGAPs | IKBKB interacting protein | 0.606 |
| ARFGAP3 | TTLL1 | ENSP00000263245 | ENSP00000266254 | ADP-ribosylation factor GTPase-activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes; ArfGAPs | Probable tubulin polyglutamylase TTLL1; Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity); Tubulin tyrosine ligase family | 0.606 |
| CLTB | ARFGAP3 | ENSP00000309415 | ENSP00000263245 | Clathrin light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family | ADP-ribosylation factor GTPase-activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes; ArfGAPs | 0.923 |
| CLTB | IKBIP | ENSP00000309415 | ENSP00000299157 | Clathrin light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family | IKBKB interacting protein | 0.593 |
| CLTB | NFU1 | ENSP00000309415 | ENSP00000387219 | Clathrin light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family | NFU1 iron-sulfur cluster scaffold homolog, mitochondrial; Iron-sulfur cluster scaffold protein which can assemble [4Fe-2S] clusters and deliver them to target proteins; Belongs to the NifU family | 0.576 |
| CLTB | SRSF7 | ENSP00000309415 | ENSP00000325905 | Clathrin light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family | Serine/arginine-rich splicing factor 7; Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific | 0.563 |
| FAM198A | IKBIP | ENSP00000407301 | ENSP00000299157 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | IKBKB interacting protein | 0.516 |
| FAM198A | ZNF662 | ENSP00000407301 | ENSP00000329264 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | Zinc finger protein 662; Zinc fingers C2H2-type | 0.663 |
| IKBIP | APAF1 | ENSP00000299157 | ENSP00000448165 | IKBKB interacting protein | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis; Apoptosome | 0.536 |
| IKBIP | ARFGAP3 | ENSP00000299157 | ENSP00000263245 | IKBKB interacting protein | ADP-ribosylation factor GTPase-activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes; ArfGAPs | 0.606 |
| IKBIP | CLTB | ENSP00000299157 | ENSP00000309415 | IKBKB interacting protein | Clathrin light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family | 0.593 |
| IKBIP | FAM198A | ENSP00000299157 | ENSP00000407301 | IKBKB interacting protein | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | 0.516 |
| IKBIP | NFU1 | ENSP00000299157 | ENSP00000387219 | IKBKB interacting protein | NFU1 iron-sulfur cluster scaffold homolog, mitochondrial; Iron-sulfur cluster scaffold protein which can assemble [4Fe-2S] clusters and deliver them to target proteins; Belongs to the NifU family | 0.604 |
| IKBIP | RPUSD4 | ENSP00000299157 | ENSP00000298317 | IKBKB interacting protein | Mitochondrial RNA pseudouridine synthase RPUSD4; Converts specific uridines to pseudouridine (PSI) in different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome. Acts on position 39 in mitochondrial tRNA(Phe); Belongs to the pseudouridine synthase RluA family | 0.812 |
| IKBIP | SRSF7 | ENSP00000299157 | ENSP00000325905 | IKBKB interacting protein | Serine/arginine-rich splicing factor 7; Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific | 0.586 |
| IKBIP | TPM3 | ENSP00000299157 | ENSP00000357516 | IKBKB interacting protein | Tropomyosin alpha-3 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family | 0.516 |
| IKBIP | TTLL1 | ENSP00000299157 | ENSP00000266254 | IKBKB interacting protein | Probable tubulin polyglutamylase TTLL1; Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity); Tubulin tyrosine ligase family | 0.629 |
| IKBIP | ZNF662 | ENSP00000299157 | ENSP00000329264 | IKBKB interacting protein | Zinc finger protein 662; Zinc fingers C2H2-type | 0.516 |
