TCP11L2 protein (human) - STRING database

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TCP11L2

T-complex protein 11-like protein 2; T-complex 11 like 2 (519 aa)

Predicted Functional Partners:

TUBA1C

0.899

TTC5

0.826

NR1D1

0.814

TUBA1A

0.795

TUBA1B

0.753

TUBA4A

0.645

TUBA3C

0.641

TUBA3E

0.625

CABYR

0.625

EPN3

0.620

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CABYR	TCP11L2	ENSP00000483621	ENSP00000299045	Calcium-binding tyrosine phosphorylation-regulated protein; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium	T-complex protein 11-like protein 2; T-complex 11 like 2	0.625
EPN3	TCP11L2	ENSP00000268933	ENSP00000299045	Epsin-3; Epsin 3; Belongs to the epsin family	T-complex protein 11-like protein 2; T-complex 11 like 2	0.620
NR1D1	TCP11L2	ENSP00000246672	ENSP00000299045	Nuclear receptor subfamily 1 group D member 1; Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for [...]	T-complex protein 11-like protein 2; T-complex 11 like 2	0.814
TCP11L2	CABYR	ENSP00000299045	ENSP00000483621	T-complex protein 11-like protein 2; T-complex 11 like 2	Calcium-binding tyrosine phosphorylation-regulated protein; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium	0.625
TCP11L2	EPN3	ENSP00000299045	ENSP00000268933	T-complex protein 11-like protein 2; T-complex 11 like 2	Epsin-3; Epsin 3; Belongs to the epsin family	0.620
TCP11L2	NR1D1	ENSP00000299045	ENSP00000246672	T-complex protein 11-like protein 2; T-complex 11 like 2	Nuclear receptor subfamily 1 group D member 1; Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for [...]	0.814
TCP11L2	TTC5	ENSP00000299045	ENSP00000258821	T-complex protein 11-like protein 2; T-complex 11 like 2	Tetratricopeptide repeat protein 5; Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity); Tetratricopeptide repeat domain containing	0.826
TCP11L2	TUBA1A	ENSP00000299045	ENSP00000301071	T-complex protein 11-like protein 2; T-complex 11 like 2	Tubulin alpha-1A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Tubulins	0.795
TCP11L2	TUBA1B	ENSP00000299045	ENSP00000336799	T-complex protein 11-like protein 2; T-complex 11 like 2	Tubulin alpha-1B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Tubulins	0.753
TCP11L2	TUBA1C	ENSP00000299045	ENSP00000301072	T-complex protein 11-like protein 2; T-complex 11 like 2	Tubulin alpha-1C chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family	0.899
TCP11L2	TUBA3C	ENSP00000299045	ENSP00000382982	T-complex protein 11-like protein 2; T-complex 11 like 2	Tubulin alpha-3C/D chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family	0.641
TCP11L2	TUBA3E	ENSP00000299045	ENSP00000318197	T-complex protein 11-like protein 2; T-complex 11 like 2	Tubulin alpha-3E chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity); Belongs to the tubulin family	0.625
TCP11L2	TUBA4A	ENSP00000299045	ENSP00000248437	T-complex protein 11-like protein 2; T-complex 11 like 2	Tubulin alpha-4A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Tubulins	0.645
TTC5	TCP11L2	ENSP00000258821	ENSP00000299045	Tetratricopeptide repeat protein 5; Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity); Tetratricopeptide repeat domain containing	T-complex protein 11-like protein 2; T-complex 11 like 2	0.826
TTC5	TUBA1A	ENSP00000258821	ENSP00000301071	Tetratricopeptide repeat protein 5; Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity); Tetratricopeptide repeat domain containing	Tubulin alpha-1A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Tubulins	0.541
TTC5	TUBA1C	ENSP00000258821	ENSP00000301072	Tetratricopeptide repeat protein 5; Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity); Tetratricopeptide repeat domain containing	Tubulin alpha-1C chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family	0.735
TUBA1A	TCP11L2	ENSP00000301071	ENSP00000299045	Tubulin alpha-1A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Tubulins	T-complex protein 11-like protein 2; T-complex 11 like 2	0.795
TUBA1A	TTC5	ENSP00000301071	ENSP00000258821	Tubulin alpha-1A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Tubulins	Tetratricopeptide repeat protein 5; Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity); Tetratricopeptide repeat domain containing	0.541
TUBA1A	TUBA1B	ENSP00000301071	ENSP00000336799	Tubulin alpha-1A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Tubulins	Tubulin alpha-1B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Tubulins	0.999
TUBA1A	TUBA1C	ENSP00000301071	ENSP00000301072	Tubulin alpha-1A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Tubulins	Tubulin alpha-1C chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family	0.935

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