| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANO5 | NELL1 | ENSP00000315371 | ENSP00000298925 | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity; Anoctamins | Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | 0.808 |
| ANO6 | NELL1 | ENSP00000409126 | ENSP00000298925 | Anoctamin-6; Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chlorid [...] | Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | 0.893 |
| ATRAID | NELL1 | ENSP00000484228 | ENSP00000298925 | All-trans retinoic acid-induced differentiation factor; Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway | Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | 0.572 |
| BMP2 | NELL1 | ENSP00000368104 | ENSP00000298925 | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4; Belongs to the TGF-beta family | Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | 0.559 |
| BMP2 | RUNX2 | ENSP00000368104 | ENSP00000360493 | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4; Belongs to the TGF-beta family | Runt-related transcription factor 2; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5’-PYGPYGGT-3’, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation- synergizes with SPEN/MINT to enhance FGFR2-mediat [...] | 0.965 |
| BMP2 | SP7 | ENSP00000368104 | ENSP00000443827 | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4; Belongs to the TGF-beta family | Transcription factor Sp7; Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity) | 0.919 |
| C12orf55 | FGD6 | ENSP00000431759 | ENSP00000344446 | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella | FYVE, RhoGEF and PH domain-containing protein 6; May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity); Pleckstrin homology domain containing | 0.641 |
| C12orf55 | NELL1 | ENSP00000431759 | ENSP00000298925 | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella | Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | 0.559 |
| EMP3 | GLT6D1 | ENSP00000270221 | ENSP00000360829 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions | Glycosyltransferase 6 domain containing 1 | 0.608 |
| EMP3 | NELL1 | ENSP00000270221 | ENSP00000298925 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions | Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | 0.657 |
| FGD6 | C12orf55 | ENSP00000344446 | ENSP00000431759 | FYVE, RhoGEF and PH domain-containing protein 6; May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity); Pleckstrin homology domain containing | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella | 0.641 |
| FGD6 | NELL1 | ENSP00000344446 | ENSP00000298925 | FYVE, RhoGEF and PH domain-containing protein 6; May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity); Pleckstrin homology domain containing | Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | 0.602 |
| GLT6D1 | EMP3 | ENSP00000360829 | ENSP00000270221 | Glycosyltransferase 6 domain containing 1 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions | 0.608 |
| GLT6D1 | NELL1 | ENSP00000360829 | ENSP00000298925 | Glycosyltransferase 6 domain containing 1 | Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | 0.561 |
| NELL1 | ANO5 | ENSP00000298925 | ENSP00000315371 | Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity; Anoctamins | 0.808 |
| NELL1 | ANO6 | ENSP00000298925 | ENSP00000409126 | Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | Anoctamin-6; Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chlorid [...] | 0.893 |
| NELL1 | ATRAID | ENSP00000298925 | ENSP00000484228 | Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | All-trans retinoic acid-induced differentiation factor; Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway | 0.572 |
| NELL1 | BMP2 | ENSP00000298925 | ENSP00000368104 | Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4; Belongs to the TGF-beta family | 0.559 |
| NELL1 | C12orf55 | ENSP00000298925 | ENSP00000431759 | Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella | 0.559 |
| NELL1 | EMP3 | ENSP00000298925 | ENSP00000270221 | Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions | 0.657 |
