node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGBL4 | TTLL5 | ENSP00000360905 | ENSP00000298832 | Cytosolic carboxypeptidase 6; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes polyglutamates from the carboxy-terminus of target proteins such as MYLK. Mediates deglutamylation of CGAS/MB21D1, regulating the antiviral activity of CGAS/MB21D1. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed b [...] | Tubulin polyglutamylase TTLL5; Polyglutamylase which preferentially modifies alpha- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction; Tubulin tyrosine ligase family | 0.703 |
CCDC138 | CCDC61 | ENSP00000295124 | ENSP00000471454 | Coiled-coil domain containing 138 | Coiled-coil domain containing 61 | 0.774 |
CCDC138 | KIAA1328 | ENSP00000295124 | ENSP00000280020 | Coiled-coil domain containing 138 | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes | 0.744 |
CCDC138 | PIBF1 | ENSP00000295124 | ENSP00000317144 | Coiled-coil domain containing 138 | Progesterone-induced-blocking factor 1; Isoform 1- Pericentriolar protein required to maintain mitotic spindle pole integrity. Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation. Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 | 0.784 |
CCDC138 | SSX2IP | ENSP00000295124 | ENSP00000340279 | Coiled-coil domain containing 138 | Afadin- and alpha-actinin-binding protein; Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E- cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement- localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via a [...] | 0.735 |
CCDC138 | TTLL5 | ENSP00000295124 | ENSP00000298832 | Coiled-coil domain containing 138 | Tubulin polyglutamylase TTLL5; Polyglutamylase which preferentially modifies alpha- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction; Tubulin tyrosine ligase family | 0.699 |
CCDC138 | WDR90 | ENSP00000295124 | ENSP00000293879 | Coiled-coil domain containing 138 | WD repeat-containing protein 90; WD repeat domain containing | 0.747 |
CCDC61 | CCDC138 | ENSP00000471454 | ENSP00000295124 | Coiled-coil domain containing 61 | Coiled-coil domain containing 138 | 0.774 |
CCDC61 | KIAA1328 | ENSP00000471454 | ENSP00000280020 | Coiled-coil domain containing 61 | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes | 0.766 |
CCDC61 | PIBF1 | ENSP00000471454 | ENSP00000317144 | Coiled-coil domain containing 61 | Progesterone-induced-blocking factor 1; Isoform 1- Pericentriolar protein required to maintain mitotic spindle pole integrity. Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation. Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 | 0.746 |
CCDC61 | SSX2IP | ENSP00000471454 | ENSP00000340279 | Coiled-coil domain containing 61 | Afadin- and alpha-actinin-binding protein; Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E- cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement- localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via a [...] | 0.720 |
CCDC61 | TTLL5 | ENSP00000471454 | ENSP00000298832 | Coiled-coil domain containing 61 | Tubulin polyglutamylase TTLL5; Polyglutamylase which preferentially modifies alpha- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction; Tubulin tyrosine ligase family | 0.729 |
CCDC61 | WDR90 | ENSP00000471454 | ENSP00000293879 | Coiled-coil domain containing 61 | WD repeat-containing protein 90; WD repeat domain containing | 0.777 |
KIAA1328 | CCDC138 | ENSP00000280020 | ENSP00000295124 | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes | Coiled-coil domain containing 138 | 0.744 |
KIAA1328 | CCDC61 | ENSP00000280020 | ENSP00000471454 | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes | Coiled-coil domain containing 61 | 0.766 |
KIAA1328 | PIBF1 | ENSP00000280020 | ENSP00000317144 | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes | Progesterone-induced-blocking factor 1; Isoform 1- Pericentriolar protein required to maintain mitotic spindle pole integrity. Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation. Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 | 0.720 |
KIAA1328 | SSX2IP | ENSP00000280020 | ENSP00000340279 | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes | Afadin- and alpha-actinin-binding protein; Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E- cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement- localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via a [...] | 0.702 |
KIAA1328 | TTLL5 | ENSP00000280020 | ENSP00000298832 | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes | Tubulin polyglutamylase TTLL5; Polyglutamylase which preferentially modifies alpha- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction; Tubulin tyrosine ligase family | 0.717 |
KIAA1328 | WDR90 | ENSP00000280020 | ENSP00000293879 | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes | WD repeat-containing protein 90; WD repeat domain containing | 0.736 |
NCOA2 | TTLL5 | ENSP00000399968 | ENSP00000298832 | Nuclear receptor coactivator 2; Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock b [...] | Tubulin polyglutamylase TTLL5; Polyglutamylase which preferentially modifies alpha- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction; Tubulin tyrosine ligase family | 0.897 |