| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C12orf29 | C12orf50 | ENSP00000349358 | ENSP00000298699 | Uncharacterized protein C12orf29; Chromosome 12 open reading frame 29 | Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50 | 0.644 |
| C12orf50 | C12orf29 | ENSP00000298699 | ENSP00000349358 | Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50 | Uncharacterized protein C12orf29; Chromosome 12 open reading frame 29 | 0.644 |
| C12orf50 | KLHL17 | ENSP00000298699 | ENSP00000343930 | Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50 | Kelch-like protein 17; Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity); BTB domain containing | 0.547 |
| C12orf50 | MGAT4C | ENSP00000298699 | ENSP00000481096 | Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50 | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage (’GnT-VI’ activity); Mannosyl-glycoprotein N-acet [...] | 0.543 |
| C12orf50 | NR2F6 | ENSP00000298699 | ENSP00000291442 | Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50 | Nuclear receptor subfamily 2 group F member 6; Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5’-AGGTCA-3’ direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcription [...] | 0.549 |
| C12orf50 | NUDT17 | ENSP00000298699 | ENSP00000334437 | Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50 | Nucleoside diphosphate-linked moiety X motif 17; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Nudix hydrolase family | 0.587 |
| C12orf50 | POLR3C | ENSP00000298699 | ENSP00000334564 | Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50 | DNA-directed RNA polymerase III subunit RPC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB- DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during [...] | 0.556 |
| C12orf50 | RSU1 | ENSP00000298699 | ENSP00000367154 | Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50 | Ras suppressor protein 1; Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro | 0.513 |
| C12orf50 | SETD3 | ENSP00000298699 | ENSP00000327436 | Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50 | Histone-lysine N-methyltransferase setd3; Histone methyltransferase that methylates ’Lys-4’ and ’Lys-36’ of histone H3 (H3K4me and H3K36me). Acts as a transcriptional activator. Plays an important role in the transcriptional regulation of muscle cell differentiation via interaction with MYOD1; SET domain containing | 0.517 |
| C12orf50 | UBR5 | ENSP00000298699 | ENSP00000429084 | Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50 | E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Pla [...] | 0.504 |
| C12orf50 | ZFP2 | ENSP00000298699 | ENSP00000354453 | Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50 | Zinc finger protein 2 homolog; Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance; Zinc fingers C2H2-type | 0.569 |
| KLHL17 | C12orf50 | ENSP00000343930 | ENSP00000298699 | Kelch-like protein 17; Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity); BTB domain containing | Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50 | 0.547 |
| KLHL17 | MGAT4C | ENSP00000343930 | ENSP00000481096 | Kelch-like protein 17; Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity); BTB domain containing | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage (’GnT-VI’ activity); Mannosyl-glycoprotein N-acet [...] | 0.509 |
| KLHL17 | NUDT17 | ENSP00000343930 | ENSP00000334437 | Kelch-like protein 17; Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity); BTB domain containing | Nucleoside diphosphate-linked moiety X motif 17; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Nudix hydrolase family | 0.585 |
| KLHL17 | POLR3C | ENSP00000343930 | ENSP00000334564 | Kelch-like protein 17; Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity); BTB domain containing | DNA-directed RNA polymerase III subunit RPC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB- DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during [...] | 0.463 |
| MGAT4C | C12orf50 | ENSP00000481096 | ENSP00000298699 | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage (’GnT-VI’ activity); Mannosyl-glycoprotein N-acet [...] | Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50 | 0.543 |
| MGAT4C | KLHL17 | ENSP00000481096 | ENSP00000343930 | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage (’GnT-VI’ activity); Mannosyl-glycoprotein N-acet [...] | Kelch-like protein 17; Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity); BTB domain containing | 0.509 |
| MGAT4C | NUDT17 | ENSP00000481096 | ENSP00000334437 | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage (’GnT-VI’ activity); Mannosyl-glycoprotein N-acet [...] | Nucleoside diphosphate-linked moiety X motif 17; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Nudix hydrolase family | 0.541 |
| MGAT4C | POLR3C | ENSP00000481096 | ENSP00000334564 | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage (’GnT-VI’ activity); Mannosyl-glycoprotein N-acet [...] | DNA-directed RNA polymerase III subunit RPC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB- DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during [...] | 0.542 |
| NR2F6 | C12orf50 | ENSP00000291442 | ENSP00000298699 | Nuclear receptor subfamily 2 group F member 6; Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5’-AGGTCA-3’ direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcription [...] | Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50 | 0.549 |
