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SLC39A6 SLC39A6 SLC39A8 SLC39A8 SLC39A5 SLC39A5 SLC39A11 SLC39A11 SLC39A7 SLC39A7 SLC30A1 SLC30A1 SLC30A4 SLC30A4 SLC39A2 SLC39A2 SLC39A14 SLC39A14 SLC39A12 SLC39A12 SLC39A4 SLC39A4
"SLC39A2" - Zinc transporter ZIP2 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
SLC39A2Zinc transporter ZIP2; Mediates zinc uptake. Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis; Solute carriers (309 aa)    
Predicted Functional Partners:
SLC39A7
Zinc transporter SLC39A7; Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+); Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily (469 aa)
     
 
  0.875
SLC39A11
Zinc transporter ZIP11; Functions as a cellular zinc transporter; Solute carriers (342 aa)
     
 
  0.871
SLC39A4
Zinc transporter ZIP4; Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability (By similarity); Solute carriers (647 aa)
     
 
  0.865
SLC39A12
Zinc transporter ZIP12; Acts as a zinc-influx transporter (Potential). May be partly involved in the outbreak of schizophrenia; Belongs to the ZIP transporter (TC 2.A.5) family (691 aa)
     
 
  0.817
SLC39A14
Zinc transporter ZIP14; Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron; Belongs to the ZIP transporter (TC 2.A.5) family (492 aa)
     
 
  0.813
SLC39A6
Zinc transporter ZIP6; May act as a zinc-influx transporter; Belongs to the ZIP transporter (TC 2.A.5) family (755 aa)
     
 
  0.798
SLC30A4
Zinc transporter 4; Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily (429 aa)
     
 
  0.793
SLC30A1
Zinc transporter 1; May be involved in zinc transport out of the cell; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily (507 aa)
     
 
  0.790
SLC39A5
Zinc transporter ZIP5; May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Plays a role in eye development. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera. Seems to play a central role in controlling organismal zinc status (By similarity); Solute carriers (540 aa)
     
 
  0.786
SLC39A8
Zinc transporter ZIP8; Acts as a manganese and zinc influx transporter. Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain; Belongs to the ZIP transporter (TC 2.A.5) family (460 aa)
     
 
  0.786
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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