node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CASC1 | CASC4 | ENSP00000379310 | ENSP00000299957 | Protein phosphatase 1 regulatory subunits | Protein CASC4; Cancer susceptibility 4; Belongs to the GOLM1/CASC4 family | 0.620 |
CASC1 | STK32C | ENSP00000379310 | ENSP00000298630 | Protein phosphatase 1 regulatory subunits | Serine/threonine kinase 32C | 0.472 |
CASC4 | CASC1 | ENSP00000299957 | ENSP00000379310 | Protein CASC4; Cancer susceptibility 4; Belongs to the GOLM1/CASC4 family | Protein phosphatase 1 regulatory subunits | 0.620 |
CASC4 | STK32C | ENSP00000299957 | ENSP00000298630 | Protein CASC4; Cancer susceptibility 4; Belongs to the GOLM1/CASC4 family | Serine/threonine kinase 32C | 0.472 |
COCH | NAGK | ENSP00000379862 | ENSP00000477639 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork; Deafness associated genes | N-acetyl-D-glucosamine kinase; Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway- although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity | 0.432 |
COCH | STK32C | ENSP00000379862 | ENSP00000298630 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork; Deafness associated genes | Serine/threonine kinase 32C | 0.504 |
DPYSL4 | STK32C | ENSP00000339850 | ENSP00000298630 | Dihydropyrimidinase-related protein 4; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family | Serine/threonine kinase 32C | 0.558 |
EVC2 | STK32C | ENSP00000342144 | ENSP00000298630 | Limbin; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Plays a critical role in bone formation and skeletal development. May be involved in early embryonic morphogenesis | Serine/threonine kinase 32C | 0.525 |
MCM5 | NAGK | ENSP00000216122 | ENSP00000477639 | DNA replication licensing factor MCM5; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | N-acetyl-D-glucosamine kinase; Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway- although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity | 0.787 |
MCM5 | STK32C | ENSP00000216122 | ENSP00000298630 | DNA replication licensing factor MCM5; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Serine/threonine kinase 32C | 0.534 |
NAGK | COCH | ENSP00000477639 | ENSP00000379862 | N-acetyl-D-glucosamine kinase; Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway- although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork; Deafness associated genes | 0.432 |
NAGK | MCM5 | ENSP00000477639 | ENSP00000216122 | N-acetyl-D-glucosamine kinase; Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway- although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity | DNA replication licensing factor MCM5; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.787 |
NAGK | STK32C | ENSP00000477639 | ENSP00000298630 | N-acetyl-D-glucosamine kinase; Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway- although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity | Serine/threonine kinase 32C | 0.527 |
PKM | STK32C | ENSP00000320171 | ENSP00000298630 | Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation a [...] | Serine/threonine kinase 32C | 0.473 |
PPP1R21 | STK32C | ENSP00000294952 | ENSP00000298630 | Protein phosphatase 1 regulatory subunit 21 | Serine/threonine kinase 32C | 0.474 |
RPTOR | STK32C | ENSP00000307272 | ENSP00000298630 | Regulatory-associated protein of mTOR; Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTO [...] | Serine/threonine kinase 32C | 0.508 |
STK32C | CASC1 | ENSP00000298630 | ENSP00000379310 | Serine/threonine kinase 32C | Protein phosphatase 1 regulatory subunits | 0.472 |
STK32C | CASC4 | ENSP00000298630 | ENSP00000299957 | Serine/threonine kinase 32C | Protein CASC4; Cancer susceptibility 4; Belongs to the GOLM1/CASC4 family | 0.472 |
STK32C | COCH | ENSP00000298630 | ENSP00000379862 | Serine/threonine kinase 32C | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork; Deafness associated genes | 0.504 |
STK32C | DPYSL4 | ENSP00000298630 | ENSP00000339850 | Serine/threonine kinase 32C | Dihydropyrimidinase-related protein 4; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family | 0.558 |