node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BBS2 | KLHDC2 | ENSP00000245157 | ENSP00000298307 | Bardet-Biedl syndrome 2 protein; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl ex [...] | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | 0.622 |
CREB3 | KLHDC2 | ENSP00000342136 | ENSP00000298307 | Cyclic AMP-responsive element-binding protein 3; Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of [...] | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | 0.948 |
CREB3 | KLHL2 | ENSP00000342136 | ENSP00000424198 | Cyclic AMP-responsive element-binding protein 3; Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of [...] | Kelch-like protein 2; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors; BTB domain containing | 0.527 |
IVNS1ABP | KLHDC2 | ENSP00000356468 | ENSP00000298307 | Influenza virus NS1A-binding protein; Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may [...] | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | 0.524 |
KLHDC2 | BBS2 | ENSP00000298307 | ENSP00000245157 | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | Bardet-Biedl syndrome 2 protein; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl ex [...] | 0.622 |
KLHDC2 | CREB3 | ENSP00000298307 | ENSP00000342136 | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | Cyclic AMP-responsive element-binding protein 3; Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of [...] | 0.948 |
KLHDC2 | IVNS1ABP | ENSP00000298307 | ENSP00000356468 | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | Influenza virus NS1A-binding protein; Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may [...] | 0.524 |
KLHDC2 | KLHL2 | ENSP00000298307 | ENSP00000424198 | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | Kelch-like protein 2; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors; BTB domain containing | 0.753 |
KLHDC2 | MKLN1 | ENSP00000298307 | ENSP00000323527 | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | Muskelin; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1; CTLH complex | 0.521 |
KLHDC2 | MTFR2 | ENSP00000298307 | ENSP00000395232 | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | Mitochondrial fission regulator 2; May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity); Belongs to the MTFR1 family | 0.547 |
KLHDC2 | PFDN5 | ENSP00000298307 | ENSP00000447942 | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | Prefoldin subunit 5; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC; Belongs to the prefoldin subunit alpha family | 0.540 |
KLHDC2 | PROS1 | ENSP00000298307 | ENSP00000377783 | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | Vitamin K-dependent protein S; Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis; Gla domain containing | 0.573 |
KLHDC2 | PTOV1 | ENSP00000298307 | ENSP00000375717 | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | Prostate tumor-overexpressed gene 1 protein; May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation | 0.549 |
KLHDC2 | UBXN8 | ENSP00000298307 | ENSP00000479216 | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | UBX domain-containing protein 8; Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction; UBX domain containing | 0.522 |
KLHL2 | CREB3 | ENSP00000424198 | ENSP00000342136 | Kelch-like protein 2; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors; BTB domain containing | Cyclic AMP-responsive element-binding protein 3; Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of [...] | 0.527 |
KLHL2 | KLHDC2 | ENSP00000424198 | ENSP00000298307 | Kelch-like protein 2; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors; BTB domain containing | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | 0.753 |
KLHL2 | MKLN1 | ENSP00000424198 | ENSP00000323527 | Kelch-like protein 2; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors; BTB domain containing | Muskelin; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1; CTLH complex | 0.722 |
MKLN1 | KLHDC2 | ENSP00000323527 | ENSP00000298307 | Muskelin; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1; CTLH complex | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | 0.521 |
MKLN1 | KLHL2 | ENSP00000323527 | ENSP00000424198 | Muskelin; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1; CTLH complex | Kelch-like protein 2; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors; BTB domain containing | 0.722 |
MTFR2 | KLHDC2 | ENSP00000395232 | ENSP00000298307 | Mitochondrial fission regulator 2; May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity); Belongs to the MTFR1 family | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding | 0.547 |