C10orf10 protein (human) - STRING database

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C10orf10

Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS (212 aa)

Predicted Functional Partners:

CRNN

0.931

RPTN

0.930

C6orf203

0.591

ZSWIM4

0.588

CSRNP3

0.587

TMEM65

0.562

FOXO3

0.562

TTC9

0.559

RASEF

0.532

CCDC58

0.524

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C10orf10	C6orf203	ENSP00000298295	ENSP00000384867	Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS	Uncharacterized protein C6orf203; Chromosome 6 open reading frame 203	0.591
C10orf10	CCDC58	ENSP00000298295	ENSP00000291458	Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS	Coiled-coil domain containing 58; Belongs to the CCDC58 family	0.524
C10orf10	CRNN	ENSP00000298295	ENSP00000271835	Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS	Cornulin; Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest; Belongs to the S100-fused protein family	0.931
C10orf10	CSRNP3	ENSP00000298295	ENSP00000318258	Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS	Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity. Plays a role in apoptosis (By similarity); Protein phosphatase 1 regulatory subunits	0.587
C10orf10	FOXO3	ENSP00000298295	ENSP00000385824	Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS	Forkhead box protein O3; Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5’-[AG]TAAA[TC]A-3’. Participates in post-transcriptional regulation of MYC- following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3’UTR of MYC transcript and prevent its translation; Forkhead boxes	0.562
C10orf10	RASEF	ENSP00000298295	ENSP00000365630	Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS	Ras and EF-hand domain-containing protein; Binds predominantly GDP, and also GTP; EF-hand domain containing	0.532
C10orf10	RPTN	ENSP00000298295	ENSP00000317895	Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS	Repetin; Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium; EF-hand domain containing	0.930
C10orf10	TMEM65	ENSP00000298295	ENSP00000297632	Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS	Transmembrane protein 65; May play an important role in cardiac development and function. May regulate cardiac conduction and the function of the gap junction protein GJA1. May contributes to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (By similarity). May also play a role in the regulation of mitochondrial respiration and mitochondrial DNA copy number maintenance	0.562
C10orf10	TTC9	ENSP00000298295	ENSP00000256367	Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS	Tetratricopeptide repeat domain containing; Belongs to the TTC9 family	0.559
C10orf10	ZSWIM4	ENSP00000298295	ENSP00000254323	Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS	Zinc finger SWIM-type containing 4	0.588
C6orf203	C10orf10	ENSP00000384867	ENSP00000298295	Uncharacterized protein C6orf203; Chromosome 6 open reading frame 203	Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS	0.591
C6orf203	CCDC58	ENSP00000384867	ENSP00000291458	Uncharacterized protein C6orf203; Chromosome 6 open reading frame 203	Coiled-coil domain containing 58; Belongs to the CCDC58 family	0.752
CCDC58	C10orf10	ENSP00000291458	ENSP00000298295	Coiled-coil domain containing 58; Belongs to the CCDC58 family	Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS	0.524
CCDC58	C6orf203	ENSP00000291458	ENSP00000384867	Coiled-coil domain containing 58; Belongs to the CCDC58 family	Uncharacterized protein C6orf203; Chromosome 6 open reading frame 203	0.752
CRNN	C10orf10	ENSP00000271835	ENSP00000298295	Cornulin; Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest; Belongs to the S100-fused protein family	Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS	0.931
CRNN	RPTN	ENSP00000271835	ENSP00000317895	Cornulin; Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest; Belongs to the S100-fused protein family	Repetin; Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium; EF-hand domain containing	0.490
CSRNP3	C10orf10	ENSP00000318258	ENSP00000298295	Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity. Plays a role in apoptosis (By similarity); Protein phosphatase 1 regulatory subunits	Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS	0.587
CSRNP3	RASEF	ENSP00000318258	ENSP00000365630	Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity. Plays a role in apoptosis (By similarity); Protein phosphatase 1 regulatory subunits	Ras and EF-hand domain-containing protein; Binds predominantly GDP, and also GTP; EF-hand domain containing	0.556
CSRNP3	TMEM65	ENSP00000318258	ENSP00000297632	Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity. Plays a role in apoptosis (By similarity); Protein phosphatase 1 regulatory subunits	Transmembrane protein 65; May play an important role in cardiac development and function. May regulate cardiac conduction and the function of the gap junction protein GJA1. May contributes to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (By similarity). May also play a role in the regulation of mitochondrial respiration and mitochondrial DNA copy number maintenance	0.623
CSRNP3	TTC9	ENSP00000318258	ENSP00000256367	Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity. Plays a role in apoptosis (By similarity); Protein phosphatase 1 regulatory subunits	Tetratricopeptide repeat domain containing; Belongs to the TTC9 family	0.574

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