DNAAF2 protein (human) - STRING database

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DNAAF2

Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment (837 aa)

Predicted Functional Partners:

DYX1C1

0.937

DNAAF3

0.926

DNAI2

0.918

HSPA4

0.861

RSPH4A

0.855

SPAG1

0.855

RSPH9

0.851

CCDC103

0.844

DNAH5

0.840

DNAI1

0.835

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC103	DNAAF2	ENSP00000391692	ENSP00000298292	Coiled-coil domain containing 103; Dynein-attachment factor required for cilia motility; Belongs to the CCDC103/PR46b family	Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment	0.844
CCDC103	DNAAF3	ENSP00000391692	ENSP00000436975	Coiled-coil domain containing 103; Dynein-attachment factor required for cilia motility; Belongs to the CCDC103/PR46b family	Dynein assembly factor 3, axonemal; Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia; Belongs to the DNAAF3 family	0.858
CCDC103	DNAH5	ENSP00000391692	ENSP00000265104	Coiled-coil domain containing 103; Dynein-attachment factor required for cilia motility; Belongs to the CCDC103/PR46b family	Dynein heavy chain 5, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles; Dyneins, axonemal	0.759
CCDC103	DNAI1	ENSP00000391692	ENSP00000480538	Coiled-coil domain containing 103; Dynein-attachment factor required for cilia motility; Belongs to the CCDC103/PR46b family	Dynein intermediate chain 1, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family	0.759
CCDC103	DNAI2	ENSP00000391692	ENSP00000400252	Coiled-coil domain containing 103; Dynein-attachment factor required for cilia motility; Belongs to the CCDC103/PR46b family	Dynein intermediate chain 2, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family	0.778
CCDC103	DYX1C1	ENSP00000391692	ENSP00000323275	Coiled-coil domain containing 103; Dynein-attachment factor required for cilia motility; Belongs to the CCDC103/PR46b family	Dynein assembly factor 4, axonemal; Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity	0.804
CCDC103	RSPH4A	ENSP00000391692	ENSP00000229554	Coiled-coil domain containing 103; Dynein-attachment factor required for cilia motility; Belongs to the CCDC103/PR46b family	Radial spoke head protein 4 homolog A; Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk which is attached to a subfiber of the outer doublet microtubule, and a bulbous head which is attached to the stalk and appears to interact with the projections from the central pair of microtubules	0.782
CCDC103	RSPH9	ENSP00000391692	ENSP00000361238	Coiled-coil domain containing 103; Dynein-attachment factor required for cilia motility; Belongs to the CCDC103/PR46b family	Radial spoke head 9 homolog	0.782
CCDC103	SPAG1	ENSP00000391692	ENSP00000373450	Coiled-coil domain containing 103; Dynein-attachment factor required for cilia motility; Belongs to the CCDC103/PR46b family	Sperm-associated antigen 1; May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity; Tetratricopeptide repeat domain containing	0.792
DNAAF2	CCDC103	ENSP00000298292	ENSP00000391692	Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment	Coiled-coil domain containing 103; Dynein-attachment factor required for cilia motility; Belongs to the CCDC103/PR46b family	0.844
DNAAF2	DNAAF3	ENSP00000298292	ENSP00000436975	Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment	Dynein assembly factor 3, axonemal; Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia; Belongs to the DNAAF3 family	0.926
DNAAF2	DNAH5	ENSP00000298292	ENSP00000265104	Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment	Dynein heavy chain 5, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles; Dyneins, axonemal	0.840
DNAAF2	DNAI1	ENSP00000298292	ENSP00000480538	Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment	Dynein intermediate chain 1, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family	0.835
DNAAF2	DNAI2	ENSP00000298292	ENSP00000400252	Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment	Dynein intermediate chain 2, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family	0.918
DNAAF2	DYX1C1	ENSP00000298292	ENSP00000323275	Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment	Dynein assembly factor 4, axonemal; Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity	0.937
DNAAF2	HSPA4	ENSP00000298292	ENSP00000302961	Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family	0.861
DNAAF2	RSPH4A	ENSP00000298292	ENSP00000229554	Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment	Radial spoke head protein 4 homolog A; Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk which is attached to a subfiber of the outer doublet microtubule, and a bulbous head which is attached to the stalk and appears to interact with the projections from the central pair of microtubules	0.855
DNAAF2	RSPH9	ENSP00000298292	ENSP00000361238	Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment	Radial spoke head 9 homolog	0.851
DNAAF2	SPAG1	ENSP00000298292	ENSP00000373450	Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment	Sperm-associated antigen 1; May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity; Tetratricopeptide repeat domain containing	0.855
DNAAF3	CCDC103	ENSP00000436975	ENSP00000391692	Dynein assembly factor 3, axonemal; Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia; Belongs to the DNAAF3 family	Coiled-coil domain containing 103; Dynein-attachment factor required for cilia motility; Belongs to the CCDC103/PR46b family	0.858

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