HDX protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

HDX

Highly divergent homeobox; POU class homeoboxes and pseudogenes (690 aa)

Predicted Functional Partners:

GSTO1

0.791

PDE5A

0.730

FAM46D

0.673

TGM3

0.655

FDX1

0.654

RPS6KA6

0.654

NSL1

0.613

EDC4

0.580

CXorf22

0.559

MB

0.556

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CXorf22	HDX	ENSP00000297866	ENSP00000297977	Cilia- and flagella-associated protein 47; Chromosome X open reading frame 22	Highly divergent homeobox; POU class homeoboxes and pseudogenes	0.559
CXorf22	RPS6KA6	ENSP00000297866	ENSP00000262752	Cilia- and flagella-associated protein 47; Chromosome X open reading frame 22	Ribosomal protein S6 kinase alpha-6; Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily	0.759
EDC4	GSTO1	ENSP00000351811	ENSP00000358727	Enhancer of mRNA-decapping protein 4; In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro); WD repeat domain containing	Glutathione S-transferase omega-1; Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid; Soluble glutathione S-transferases	0.740
EDC4	HDX	ENSP00000351811	ENSP00000297977	Enhancer of mRNA-decapping protein 4; In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro); WD repeat domain containing	Highly divergent homeobox; POU class homeoboxes and pseudogenes	0.580
FAM46D	HDX	ENSP00000443410	ENSP00000297977	Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	Highly divergent homeobox; POU class homeoboxes and pseudogenes	0.673
FAM46D	RPS6KA6	ENSP00000443410	ENSP00000262752	Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	Ribosomal protein S6 kinase alpha-6; Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily	0.678
FDX1	HDX	ENSP00000260270	ENSP00000297977	Adrenodoxin, mitochondrial; Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage; Belongs to the adrenodoxin/putidaredoxin family	Highly divergent homeobox; POU class homeoboxes and pseudogenes	0.654
GSTO1	EDC4	ENSP00000358727	ENSP00000351811	Glutathione S-transferase omega-1; Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid; Soluble glutathione S-transferases	Enhancer of mRNA-decapping protein 4; In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro); WD repeat domain containing	0.740
GSTO1	HDX	ENSP00000358727	ENSP00000297977	Glutathione S-transferase omega-1; Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid; Soluble glutathione S-transferases	Highly divergent homeobox; POU class homeoboxes and pseudogenes	0.791
GSTO1	PDE5A	ENSP00000358727	ENSP00000347046	Glutathione S-transferase omega-1; Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid; Soluble glutathione S-transferases	cGMP-specific 3’,5’-cyclic phosphodiesterase; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5’- GMP. Specifically regulates nitric-oxide-generated cGMP; Phosphodiesterases	0.763
GSTO1	TGM3	ENSP00000358727	ENSP00000370867	Glutathione S-transferase omega-1; Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid; Soluble glutathione S-transferases	Protein-glutamine gamma-glutamyltransferase E; Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the g [...]	0.839
HDX	CXorf22	ENSP00000297977	ENSP00000297866	Highly divergent homeobox; POU class homeoboxes and pseudogenes	Cilia- and flagella-associated protein 47; Chromosome X open reading frame 22	0.559
HDX	EDC4	ENSP00000297977	ENSP00000351811	Highly divergent homeobox; POU class homeoboxes and pseudogenes	Enhancer of mRNA-decapping protein 4; In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro); WD repeat domain containing	0.580
HDX	FAM46D	ENSP00000297977	ENSP00000443410	Highly divergent homeobox; POU class homeoboxes and pseudogenes	Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	0.673
HDX	FDX1	ENSP00000297977	ENSP00000260270	Highly divergent homeobox; POU class homeoboxes and pseudogenes	Adrenodoxin, mitochondrial; Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage; Belongs to the adrenodoxin/putidaredoxin family	0.654
HDX	GSTO1	ENSP00000297977	ENSP00000358727	Highly divergent homeobox; POU class homeoboxes and pseudogenes	Glutathione S-transferase omega-1; Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid; Soluble glutathione S-transferases	0.791
HDX	MB	ENSP00000297977	ENSP00000380489	Highly divergent homeobox; POU class homeoboxes and pseudogenes	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles	0.556
HDX	NSL1	ENSP00000297977	ENSP00000355944	Highly divergent homeobox; POU class homeoboxes and pseudogenes	Kinetochore-associated protein NSL1 homolog; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis	0.613
HDX	PDE5A	ENSP00000297977	ENSP00000347046	Highly divergent homeobox; POU class homeoboxes and pseudogenes	cGMP-specific 3’,5’-cyclic phosphodiesterase; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5’- GMP. Specifically regulates nitric-oxide-generated cGMP; Phosphodiesterases	0.730
HDX	RPS6KA6	ENSP00000297977	ENSP00000262752	Highly divergent homeobox; POU class homeoboxes and pseudogenes	Ribosomal protein S6 kinase alpha-6; Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily	0.654

page 1 of 2

Network

Cooccurrence

Textmining

Coexpression

Experiments

Neighborhood

Databases

Fusion

© STRING Consortium 2020

Credits

Access

Info

About