node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALKBH6 | CCDC136 | ENSP00000368152 | ENSP00000297788 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6; Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron; Belongs to the alkB family | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization | 0.678 |
CCDC136 | ALKBH6 | ENSP00000297788 | ENSP00000368152 | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6; Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron; Belongs to the alkB family | 0.678 |
CCDC136 | GCC2 | ENSP00000297788 | ENSP00000307939 | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 | 0.564 |
CCDC136 | GKN2 | ENSP00000297788 | ENSP00000329292 | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization | Gastrokine-2; BRICHOS domain containing | 0.931 |
CCDC136 | KXD1 | ENSP00000297788 | ENSP00000472836 | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization | KxDL motif-containing protein 1; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May be involved in the biogenesis of lysosome-related organelles such as melanosomes (By similarity); Belongs to the KXD1 family | 0.527 |
CCDC136 | MEGF10 | ENSP00000297788 | ENSP00000274473 | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization | Multiple epidermal growth factor-like domains protein 10; Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum. Plays role in muscle cell proliferation, adhesion and motility. [...] | 0.810 |
CCDC136 | MEGF11 | ENSP00000297788 | ENSP00000386908 | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization | Multiple epidermal growth factor-like domains protein 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity); Belongs to the MEGF family | 0.585 |
CCDC136 | MEGF6 | ENSP00000297788 | ENSP00000348982 | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6 | 0.545 |
CCDC136 | SPACA1 | ENSP00000297788 | ENSP00000237201 | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization | Sperm acrosome membrane-associated protein 1; May be involved in sperm-egg fusion | 0.567 |
CCDC136 | TMEM8B | ENSP00000297788 | ENSP00000367227 | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization | Transmembrane protein 8B; May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion; Belongs to the TMEM8 family | 0.571 |
CCDC136 | VSTM2B | ENSP00000297788 | ENSP00000335038 | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization | V-set and transmembrane domain containing 2B | 0.632 |
GCC2 | CCDC136 | ENSP00000307939 | ENSP00000297788 | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization | 0.564 |
GKN2 | CCDC136 | ENSP00000329292 | ENSP00000297788 | Gastrokine-2; BRICHOS domain containing | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization | 0.931 |
KXD1 | CCDC136 | ENSP00000472836 | ENSP00000297788 | KxDL motif-containing protein 1; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May be involved in the biogenesis of lysosome-related organelles such as melanosomes (By similarity); Belongs to the KXD1 family | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization | 0.527 |
MEGF10 | CCDC136 | ENSP00000274473 | ENSP00000297788 | Multiple epidermal growth factor-like domains protein 10; Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum. Plays role in muscle cell proliferation, adhesion and motility. [...] | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization | 0.810 |
MEGF11 | CCDC136 | ENSP00000386908 | ENSP00000297788 | Multiple epidermal growth factor-like domains protein 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity); Belongs to the MEGF family | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization | 0.585 |
MEGF6 | CCDC136 | ENSP00000348982 | ENSP00000297788 | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6 | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization | 0.545 |
SPACA1 | CCDC136 | ENSP00000237201 | ENSP00000297788 | Sperm acrosome membrane-associated protein 1; May be involved in sperm-egg fusion | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization | 0.567 |
TMEM8B | CCDC136 | ENSP00000367227 | ENSP00000297788 | Transmembrane protein 8B; May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion; Belongs to the TMEM8 family | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization | 0.571 |
VSTM2B | CCDC136 | ENSP00000335038 | ENSP00000297788 | V-set and transmembrane domain containing 2B | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization | 0.632 |