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  • 11.0 [archived version]
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MEGF10 MEGF10 KXD1 KXD1 MEGF11 MEGF11 ALKBH6 ALKBH6 TMEM8B TMEM8B CCDC136 CCDC136 MEGF6 MEGF6 SPACA1 SPACA1 VSTM2B VSTM2B GKN2 GKN2 GCC2 GCC2
"CCDC136" - Coiled-coil domain-containing protein 136 in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CCDC136Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization (1154 aa)    
Predicted Functional Partners:
GKN2
Gastrokine-2; BRICHOS domain containing (184 aa)
           
  0.931
MEGF10
Multiple epidermal growth factor-like domains protein 10; Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum. Plays role in muscle cell proliferation, adhesion and motility. [...] (1140 aa)
     
   
  0.810
ALKBH6
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6; Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron; Belongs to the alkB family (266 aa)
           
  0.678
VSTM2B
V-set and transmembrane domain containing 2B (285 aa)
     
   
  0.632
MEGF11
Multiple epidermal growth factor-like domains protein 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity); Belongs to the MEGF family (1044 aa)
     
   
  0.585
TMEM8B
Transmembrane protein 8B; May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion; Belongs to the TMEM8 family (472 aa)
           
  0.571
SPACA1
Sperm acrosome membrane-associated protein 1; May be involved in sperm-egg fusion (294 aa)
           
  0.567
GCC2
GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 (1684 aa)
     
      0.564
MEGF6
Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6 (1541 aa)
           
  0.545
KXD1
KxDL motif-containing protein 1; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May be involved in the biogenesis of lysosome-related organelles such as melanosomes (By similarity); Belongs to the KXD1 family (176 aa)
       
      0.527
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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