• Version:
  • 11.0 [archived version]
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FAM219A FAM219A RPP25L RPP25L ARID3C ARID3C SPEF1 SPEF1 FAM205A FAM205A KIAA1161 KIAA1161 C9orf24 C9orf24 RXFP2 RXFP2 MMEL1 MMEL1 PKDREJ PKDREJ PHF7 PHF7
"C9orf24" - Spermatid-specific manchette-related protein 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
C9orf24Spermatid-specific manchette-related protein 1; May play a role in spermatogenesis (By similarity). May be involved in differentiation or function of ciliated cells; Belongs to the SMRP1 family (262 aa)    
Predicted Functional Partners:
KIAA1161
Myogenesis-regulating glycosidase; Putative glycosidase. Promotes myogenesis by activating AKT signaling through the maturation and secretion of IGF2; Belongs to the glycosyl hydrolase 31 family (714 aa)
 
       
  0.756
PKDREJ
Polycystic kidney disease and receptor for egg jelly-related protein; May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm; Belongs to the polycystin family (2253 aa)
           
  0.644
RXFP2
Relaxin receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (754 aa)
     
   
  0.627
PHF7
PHD finger protein 7; May play a role in spermatogenesis; PHD finger proteins (381 aa)
     
   
  0.593
SPEF1
Sperm flagellar protein 1; Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity). Microtubule- associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (By similarity) (236 aa)
     
   
  0.591
FAM219A
Protein FAM219A; Family with sequence similarity 219 member A (185 aa)
           
  0.555
RPP25L
Ribonuclease P protein subunit p25-like protein; May be a component of ribonuclease P or MRP (163 aa)
           
  0.547
FAM205A
Protein FAM205A; Family with sequence similarity 205 member A (1335 aa)
           
  0.526
ARID3C
AT-rich interactive domain-containing protein 3C; AT-rich interaction domain containing (412 aa)
           
  0.499
MMEL1
Membrane metallo-endopeptidase-like 1; Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity); Belongs to the peptidase M13 family (779 aa)
           
  0.478
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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