| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANXA13 | CSMD3 | ENSP00000262219 | ENSP00000297405 | Annexin A13; Belongs to the annexin family | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | 0.800 |
| ANXA13 | EXT1 | ENSP00000262219 | ENSP00000367446 | Annexin A13; Belongs to the annexin family | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan; Exostosin glycosyltransferase family | 0.710 |
| ANXA13 | RHNO1 | ENSP00000262219 | ENSP00000479598 | Annexin A13; Belongs to the annexin family | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1; Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation | 0.836 |
| ANXA13 | TRPS1 | ENSP00000262219 | ENSP00000379065 | Annexin A13; Belongs to the annexin family | Zinc finger transcription factor Trps1; Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes; GATA zinc finger domain containing | 0.649 |
| CSMD3 | ANXA13 | ENSP00000297405 | ENSP00000262219 | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | Annexin A13; Belongs to the annexin family | 0.800 |
| CSMD3 | DPH6 | ENSP00000297405 | ENSP00000256538 | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity) | 0.623 |
| CSMD3 | EXT1 | ENSP00000297405 | ENSP00000367446 | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan; Exostosin glycosyltransferase family | 0.640 |
| CSMD3 | GRID2 | ENSP00000297405 | ENSP00000282020 | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | Glutamate receptor ionotropic, delta-2; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine- dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID2 subfamily | 0.688 |
| CSMD3 | HYDIN | ENSP00000297405 | ENSP00000377197 | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | Hydrocephalus-inducing protein homolog; Required for ciliary motility; Protein phosphatase 1 regulatory subunits | 0.634 |
| CSMD3 | INTS2 | ENSP00000297405 | ENSP00000414237 | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | Integrator complex subunit 2; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex | 0.686 |
| CSMD3 | LDLRAD3 | ENSP00000297405 | ENSP00000318607 | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | Low-density lipoprotein receptor class A domain-containing protein 3; May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production | 0.688 |
| CSMD3 | RHNO1 | ENSP00000297405 | ENSP00000479598 | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1; Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation | 0.801 |
| CSMD3 | TRPS1 | ENSP00000297405 | ENSP00000379065 | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | Zinc finger transcription factor Trps1; Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes; GATA zinc finger domain containing | 0.765 |
| CSMD3 | ZHX2 | ENSP00000297405 | ENSP00000314709 | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | Zinc fingers and homeoboxes protein 2; Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA; ZF class homeoboxes and pseudogenes | 0.662 |
| DPH6 | CSMD3 | ENSP00000256538 | ENSP00000297405 | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity) | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | 0.623 |
| DPH6 | HYDIN | ENSP00000256538 | ENSP00000377197 | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity) | Hydrocephalus-inducing protein homolog; Required for ciliary motility; Protein phosphatase 1 regulatory subunits | 0.629 |
| DPH6 | LDLRAD3 | ENSP00000256538 | ENSP00000318607 | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity) | Low-density lipoprotein receptor class A domain-containing protein 3; May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production | 0.608 |
| EXT1 | ANXA13 | ENSP00000367446 | ENSP00000262219 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan; Exostosin glycosyltransferase family | Annexin A13; Belongs to the annexin family | 0.710 |
| EXT1 | CSMD3 | ENSP00000367446 | ENSP00000297405 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan; Exostosin glycosyltransferase family | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | 0.640 |
| EXT1 | RHNO1 | ENSP00000367446 | ENSP00000479598 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan; Exostosin glycosyltransferase family | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1; Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation | 0.712 |
