node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASPN | COL3A1 | ENSP00000364694 | ENSP00000304408 | Asporin; Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cart [...] | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 | 0.839 |
ASPN | FMOD | ENSP00000364694 | ENSP00000347041 | Asporin; Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cart [...] | Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily | 0.480 |
ASPN | FNDC1 | ENSP00000364694 | ENSP00000297267 | Asporin; Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cart [...] | Fibronectin type III domain-containing protein 1; May be an activator of G protein signaling; Fibronectin type III domain containing | 0.611 |
C1orf27 | CARF | ENSP00000287859 | ENSP00000384006 | Protein odr-4 homolog; May play a role in the trafficking of a subset of G- protein coupled receptors; Belongs to the ODR-4 family | Calcium-responsive transcription factor; Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5’-CTATTTCGAG-3’ sequence | 0.761 |
C1orf27 | CCDC173 | ENSP00000287859 | ENSP00000391504 | Protein odr-4 homolog; May play a role in the trafficking of a subset of G- protein coupled receptors; Belongs to the ODR-4 family | Coiled-coil domain containing 173 | 0.828 |
C1orf27 | FNDC1 | ENSP00000287859 | ENSP00000297267 | Protein odr-4 homolog; May play a role in the trafficking of a subset of G- protein coupled receptors; Belongs to the ODR-4 family | Fibronectin type III domain-containing protein 1; May be an activator of G protein signaling; Fibronectin type III domain containing | 0.647 |
CARF | C1orf27 | ENSP00000384006 | ENSP00000287859 | Calcium-responsive transcription factor; Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5’-CTATTTCGAG-3’ sequence | Protein odr-4 homolog; May play a role in the trafficking of a subset of G- protein coupled receptors; Belongs to the ODR-4 family | 0.761 |
CARF | CCDC173 | ENSP00000384006 | ENSP00000391504 | Calcium-responsive transcription factor; Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5’-CTATTTCGAG-3’ sequence | Coiled-coil domain containing 173 | 0.775 |
CARF | FNDC1 | ENSP00000384006 | ENSP00000297267 | Calcium-responsive transcription factor; Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5’-CTATTTCGAG-3’ sequence | Fibronectin type III domain-containing protein 1; May be an activator of G protein signaling; Fibronectin type III domain containing | 0.556 |
CCDC173 | C1orf27 | ENSP00000391504 | ENSP00000287859 | Coiled-coil domain containing 173 | Protein odr-4 homolog; May play a role in the trafficking of a subset of G- protein coupled receptors; Belongs to the ODR-4 family | 0.828 |
CCDC173 | CARF | ENSP00000391504 | ENSP00000384006 | Coiled-coil domain containing 173 | Calcium-responsive transcription factor; Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5’-CTATTTCGAG-3’ sequence | 0.775 |
CCDC173 | FNDC1 | ENSP00000391504 | ENSP00000297267 | Coiled-coil domain containing 173 | Fibronectin type III domain-containing protein 1; May be an activator of G protein signaling; Fibronectin type III domain containing | 0.572 |
COL3A1 | ASPN | ENSP00000304408 | ENSP00000364694 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 | Asporin; Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cart [...] | 0.839 |
COL3A1 | FMOD | ENSP00000304408 | ENSP00000347041 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 | Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily | 0.790 |
COL3A1 | FNDC1 | ENSP00000304408 | ENSP00000297267 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 | Fibronectin type III domain-containing protein 1; May be an activator of G protein signaling; Fibronectin type III domain containing | 0.571 |
DOK6 | FNDC1 | ENSP00000372160 | ENSP00000297267 | Docking protein 6; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret- mediated neurite growth. May have a role in brain development and/or maintenance | Fibronectin type III domain-containing protein 1; May be an activator of G protein signaling; Fibronectin type III domain containing | 0.567 |
FMOD | ASPN | ENSP00000347041 | ENSP00000364694 | Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily | Asporin; Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cart [...] | 0.480 |
FMOD | COL3A1 | ENSP00000347041 | ENSP00000304408 | Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 | 0.790 |
FMOD | FNDC1 | ENSP00000347041 | ENSP00000297267 | Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily | Fibronectin type III domain-containing protein 1; May be an activator of G protein signaling; Fibronectin type III domain containing | 0.662 |
FMOD | MYLIP | ENSP00000347041 | ENSP00000349298 | Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily | E3 ubiquitin-protein ligase MYLIP; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol- dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR [...] | 0.440 |