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  • 11.0 [archived version]
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MYH6 MYH6 PTCHD3 PTCHD3 PLAGL2 PLAGL2 SNX33 SNX33 ENC1 ENC1 NWD2 NWD2 GNAT3 GNAT3 GPR85 GPR85 INSIG1 INSIG1 GPR61 GPR61 INSIG2 INSIG2
"GPR85" - Probable G-protein coupled receptor 85 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
GPR85Probable G-protein coupled receptor 85; Orphan receptor; Belongs to the G-protein coupled receptor 1 family (370 aa)    
Predicted Functional Partners:
INSIG2
Insulin-induced gene 2 protein; Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR (225 aa)
           
  0.746
ENC1
Ectoderm-neural cortex protein 1; Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism; BTB domain containing (589 aa)
           
  0.740
PTCHD3
Patched domain-containing protein 3; May play a role in sperm development or sperm function (767 aa)
     
   
  0.674
NWD2
NACHT and WD repeat domain containing 2 (1742 aa)
     
   
  0.649
INSIG1
Insulin-induced gene 1 protein; Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play [...] (277 aa)
           
  0.640
PLAGL2
Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Zinc fingers C2H2-type (496 aa)
       
 
  0.622
GPR61
Probable G-protein coupled receptor 61; Orphan receptor; Belongs to the G-protein coupled receptor 1 family (451 aa)
     
   
  0.618
SNX33
Sorting nexin-33; Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macr [...] (574 aa)
           
  0.609
MYH6
Myosin-6; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family (1939 aa)
     
 
  0.602
GNAT3
Guanine nucleotide-binding protein G(t) subunit alpha-3; Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultima [...] (354 aa)
       
 
  0.597
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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