• Version:
  • 11.0 [archived version]
STRINGSTRING
LHX1 LHX1 ARX ARX PRDM13 PRDM13 LMO1 LMO1 TLX3 TLX3 LMX1B LMX1B NUP214 NUP214 TAL1 TAL1 LYL1 LYL1 PHF6 PHF6 LMO2 LMO2
"TLX3" - T-cell leukemia homeobox protein 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TLX3T-cell leukemia homeobox protein 3; NKL subclass homeoboxes and pseudogenes (291 aa)    
Predicted Functional Partners:
ARX
Homeobox protein ARX; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate; Belongs to the paired homeobox family. Bicoid subfamily (562 aa)
     
 
0.787
LMX1B
LIM homeobox transcription factor 1-beta; Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels; LIM class homeoboxes (406 aa)
     
 
  0.763
PHF6
PHD finger protein 6; Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription; PHD finger proteins (365 aa)
       
 
  0.761
LMO1
Rhombotin-1; May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors; LIM domain containing (156 aa)
     
 
  0.756
PRDM13
PR domain zinc finger protein 13; May be involved in transcriptional regulation; PR/SET domain family (707 aa)
     
 
  0.740
LHX1
LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis; LIM class homeoboxes (406 aa)
     
 
  0.726
LMO2
Rhombotin-2; Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state; LIM domain containing (227 aa)
     
 
  0.707
TAL1
T-cell acute lymphocytic leukemia protein 1; Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity); Basic helix-loop-helix proteins (331 aa)
     
 
  0.691
LYL1
Protein lyl-1; LYL1, basic helix-loop-helix family member (280 aa)
     
 
  0.679
NUP214
Nuclear pore complex protein Nup214; May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex; Nucleoporins (2090 aa)
           
  0.644
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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